Results 81 to 90 of about 6,833,641 (305)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A reverse crystal Engineering approach

, 2013
The enormous impact of crystal engineering in modern solid state chemistry takes advantage from the connection between a typical basic science field and the word engineering.
Macchi, Piero
core  

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Mechanism Design with Singularity Avoidance of Crystal-Inspired Deployable Structures

, 2019
Although deployable structures have important applications in various fields, developing a new form of structural configuration faces some scientific challenges.
Jian Feng, Yao Chen, Jiayi Yan
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Abnormal lattice occupation of Mo and related polarons in LiNbO3: Hybrid density functional theory investigation

Journal of Materiomics, 2020
Studies have reported that Mo-doped LiNbO3 exhibits excellent photorefractive performance, which may be attributed to the Mo abnormally occupation in Nb sites (MoNb) and the MoNb photorefractive centres.
Lili Li, Yanlu Li, Xian Zhao, Xiufeng Cheng, Yongjun Fan   +4 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Reversible conductivity modulation by tuning surface band bending in Sn-doped β-Ga2O3 single crystal

APL Materials
Developing methods for modulating the band structure of semiconductor material is crucial for the application. In this work, the electron concentration of heavy Sn doped β-Ga2O3 crystals showed an interesting partially reversible phenomenon after ...
Yiyuan Liu, Jiahao Yao, Huihui Li, Zhitai Jia, Jiandong Ye, Xutang Tao, Wenxiang Mu   +6 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Advances in Crystal Growth: Pioneering Materials for Tomorrow’s Technologies

Crystal growth is inherently multidisciplinary, encompassing fields such as thermodynamics and kinetics, fluid dynamics, solution and solid-state chemistry, process engineering, and defects engineering to name a few [...
David Wenhua Bi, Arnaud Magrez, Magrez, Arnaud, Bi, David Wenhua, Yong Liu, Liu, Yong   +5 more
core   +1 more source