Results 71 to 80 of about 285,778 (313)

Charge densities and crystal engineering [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2011
This chapter discusses the ways in which the present techniques and tools of charge density analysis can contribute to the burgeoning field of crystal engineering. The principal focus is on use of theoretical and experimental charge densities, Hirshfeld surface analysis, as well as the calculation of energies of intermolecular interactions and their ...
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Crystal engineering of nanomaterials to widen the lithium ion rocking “Express Way” : a case in LiCoO2

, 2012
Hexagonal LiCoO2 nanomesh is fabricated for the first time based on the low crystal mismatch strategy. From the precursor of (NH4)2Co8(CO3)6(OH)6·4H2O nanosheet to Co3O4 nanomesh and finally to LiCoO2 nanomesh, the crystal mismatch ranges from 0 to 13 ...
Wang, Yu, Zhang, Huijuan, Wong, Chee Cheong   +2 more
core   +1 more source

Crystal Engineering in Continuous Plug-Flow Crystallizers [PDF]

Crystal Growth & Design, 2017
Size, shape, and polymorphic form are the critical attributes of crystalline particles and represent the major focus of today's crystallization process design. This work demonstrates how crystal properties can be tuned efficiently in solution via a tubular crystallizer that facilitates rapid temperature cycling.
Maximilian O. Besenhard, Peter Neugebauer, Otto Scheibelhofer, Johannes G. Khinast   +3 more
openaire   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Understanding the rich physics of light propagation in slow photonic crystal waveguides

, 2010
Selected papers. Held as part of SPIE Photonics West 2010.We study propagation losses in slow light photonic crystal waveguides and show that dispersion engineering can reduce the loss.
Lalanne, Phillippe, De La Rue, Richard, Beggs, Daryl M., M. Sorel, MELLONI, ANDREA IVANO, Thomas F. Krauss, Francesco Morichetti, Schulz, Sebastian, Beggs, Daryl Matthew, Sebastian Schulz, Marc Sorel, Samarelli, Antonio, Liam O'Faolain, Krauss, Thomas F., Daryl M. Beggs, Sorel, Marc, Simon Mazoyer, L. O'Faolain, Morichetti, Francesco, D. M. Beggs, S. Schulz, Canciamilla, Antonio, A. Samarelli, TORREGIANI, MATTEO ALDO, O'Faolain, Liam, Antonio Samarelli, Andrea Melloni, Torregiani, M., Richard De La Rue, Phillippe Lalanne, Melloni, Andrea, Antonio Canciamilla, T. F. Krauss, Mazoyer, Simon, R. De La Rue, M. Torregiani   +35 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Impact of Crystal Habit on Solubility of Ticagrelor

, 2019
Drugs with poor biopharmaceutical performance are the main obstacle to the development and design of medicinal preparations. The anisotropic surface chemistry of different surfaces on the crystal influences its physical and chemical properties, such as ...
Jie Shen, Kaxi Yu, Xiurong Hu, Chi Uyen Phan, Jiyong Liu, Guanxi Chen, Jianyue Feng, Yan Ren   +7 more
core   +1 more source

Short Fluoroalkanes Suppress a Thermally-Induced Phase Transition in a Layered Organic Crystal

, 2023
Ensuring a consistent crystal structure over a wide temperature range can be desirable behaviour in organic devices. This study investigates a layered crystal system formed by hydrogen-bonded chloro-s-triazine rings functionalised with alkyl or ...
Naresh Kumar, David M. Miskovic, Anne M. Rich, Mohan M. Bhadbhade, Christopher E. Marjo, Saroj Bhattacharyya, Songyan Yin, Vina R. Aldilla   +7 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source