Results 41 to 50 of about 34,619 (259)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Controlling crystal morphology of anisotropic zeolites with elemental composition [PDF]

O.V. acknowledges the support of Charles University through the project “Grant Schemes at CU” (Reg. no. CZ.02.2.69/0.0/0.0/19_073/0016935). J.Č. acknowledges the support of the Czech Science Foundation through the project ExPro (19-27551X).
Roth, Wiesław, Roth, Wiesław J., Morris, Russell E., Veselý, Ondřej, Čejka, Jiří, Shamzhy, Mariya   +5 more
core   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Morphological and Surface Microtopographic Features of HPHT-Grown Diamond Crystals with Contact Twinning

Crystals, 2022
Gem-grade twinned high-pressure high-temperature (HPHT) synthetic diamond crystals are rare. Hence, few investigations on their morphological features and formation have been reported.
Kaiyue Sun, Taijin Lu, Mingyue He, Zhonghua Song, Jian Zhang, Jie Ke   +5 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Effects of Different Shade Treatments on the Epidermal Wax Deposition of Hosta Genotypes with Different Glaucousness of Leaf Surface

Horticulturae
Epidermal wax is strategically situated at the interface between plants and air; therefore, it plays a key role in plants’ interactions with their surroundings. It is also unstable and susceptible to light intensity.
Ping Guan, Siyu Chen, Jiaying Sun, Shuyi Zhao, Ren Fan, Yufeng Xu, Bo Qu   +6 more
doaj   +1 more source

An Optical Microscope Study of the Morphology of Xenon Hydrate Crystals: Exploring New Approaches to Cryopreservation

Crystals, 2019
One of the possible approaches to a new method of cryopreservation seems to be the controlled formation of a multitude of small crystals in an object, which, due to their size, will not damage cellular structures.
Alexey Kobelev, Valery Yashin, Nikita Penkov, Nikolay Shvirst, Mikhail Goltyaev, Anatoliy Kovtun, Eugeny Fesenko   +6 more
doaj   +1 more source

Characterization of high-H2O2-tolerant bacterial cytochrome P450 CYP105D18: insights into papaverine N-oxidation

IUCrJ, 2021
The bacterial CYP105 family is involved in secondary metabolite biosynthetic pathways and plays essential roles in the biotransformation of xenobiotics.
Bashu Dev Pardhe, Hackwon Do, Chang-Sook Jeong, Ki-Hwa Kim, Jun Hyuck Lee, Tae-Jin Oh   +5 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Structural aspects of displacive transformations: what can optical microscopy contribute? Dehydration of Sm2(C2O4)3·10H2O as a case study

IUCrJ, 2017
For martensitic transformations the macroscopic crystal strain is directly related to the corresponding structural rearrangement at the microscopic level.
Alexander A. Matvienko, Daniel V. Maslennikov, Boris A. Zakharov, Anatoly A. Sidelnikov, Stanislav A. Chizhik, Elena V. Boldyreva   +5 more
doaj   +1 more source