Results 51 to 60 of about 462,393 (297)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

A Searchable Database of Crystallization Cocktails in the PDB: Analyzing the Chemical Condition Space

open access: yesPatterns, 2020
Summary: Nearly 90% of structural models in the Protein Data Bank (PDB), the central resource worldwide for three-dimensional structural information, are currently derived from macromolecular crystallography (MX).
Miranda L. Lynch   +2 more
doaj   +1 more source

Complex Fractional-Order LQIR for Inverted-Pendulum-Type Robotic Mechanisms: Design and Experimental Validation

open access: yesMathematics, 2023
This article presents a systematic approach to formulate and experimentally validate a novel Complex Fractional Order (CFO) Linear Quadratic Integral Regulator (LQIR) design to enhance the robustness of inverted-pendulum-type robotic mechanisms against ...
Omer Saleem, Faisal Abbas, Jamshed Iqbal
doaj   +1 more source

A superelastochromic crystal [PDF]

open access: yesNature Communications, 2020
AbstractChromism—color changes by external stimuli—has been intensively studied to develop smart materials because of easily detectability of the stimuli by eye or common spectroscopy as color changes. Luminescent chromism has particularly attracted research interest because of its high sensitivity. The color changes typically proceed in a one-way, two-
Toshiki Mutai   +5 more
openaire   +3 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

An Overview of Nanomaterials for Water and Wastewater Treatment

open access: yesAdvances in Materials Science and Engineering, 2016
Due to the exceptional characteristics which resulted from nanoscale size, such as improved catalysis and adsorption properties as well as high reactivity, nanomaterials have been the subject of active research and development worldwide in recent years ...
Haijiao Lu   +5 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Crystallization behavior and morphological features of ethylene-vinyl alcohol 44 copolymer

open access: yeseXPRESS Polymer Letters, 2022
This work is a first attempt to study the crystallization behavior of ethylene-vinyl alcohol copolymer with 44 mol% of ethylene units (EVOH44) and to observe the supermolecular structures developed during its crystallization.
Clement Freymond   +6 more
doaj   +1 more source

Computational crystallization [PDF]

open access: yesArchives of Biochemistry and Biophysics, 2016
Crystallization is a key step in macromolecular structure determination by crystallography. While a robust theoretical treatment of the process is available, due to the complexity of the system, the experimental process is still largely one of trial and error.
Altan, Irem   +2 more
openaire   +3 more sources

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