Results 71 to 80 of about 303,242 (267)

Seven New Irbesartan Salts: Significantly Improved Dissolution, Excellent Hygrothermal Stability, and Characteristic Supramolecular Synthons

Crystals
Irbesartan (IRB) is a commonly used BCS Class II antihypertensive drug requiring dissolving capacity enhancement to address oral bioavailability limitations.
Junxiao Wang, Chuanhua Wu, Menglong Zhang, Lingli Hou, Wei Chen, Dingding Jing, Ying Bao   +6 more
doaj   +1 more source

An Overview of Nanomaterials for Water and Wastewater Treatment

Advances in Materials Science and Engineering, 2016
Due to the exceptional characteristics which resulted from nanoscale size, such as improved catalysis and adsorption properties as well as high reactivity, nanomaterials have been the subject of active research and development worldwide in recent years ...
Haijiao Lu, Jingkang Wang, Marco Stoller, Ting Wang, Ying Bao, Hongxun Hao   +5 more
doaj   +1 more source

A Searchable Database of Crystallization Cocktails in the PDB: Analyzing the Chemical Condition Space

Patterns, 2020
Summary: Nearly 90% of structural models in the Protein Data Bank (PDB), the central resource worldwide for three-dimensional structural information, are currently derived from macromolecular crystallography (MX).
Miranda L. Lynch, Max F. Dudek, Sarah E.J. Bowman   +2 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

A Bond-Level Sequence Framework for Molecular Representation Learning with Structural Constraints

Molecules
Molecular property prediction is a fundamental task in drug discovery and materials design. While graph neural networks (GNNs) and SMILES-based Transformers have made significant strides, the former are often limited by local message-passing bottlenecks ...
Haoran Fan, Haoqiang Qi, Xin Huang, Dongyang Zhu, Na Wang, Ting Wang, Hongxun Hao   +6 more
doaj   +1 more source

Consistency and variability of cocrystals containing positional isomers: the self-assembly evolution mechanism of supramolecular synthons of cresol–piperazine

IUCrJ, 2019
The disposition of functional groups can induce variations in the nature and type of interactions and hence affect the molecular recognition and self-assembly mechanism in cocrystals. To better understand the formation of cocrystals on a molecular level,
Na Wang, Xin Huang, Lihang Chen, Jinyue Yang, Xin Li, Jiayuan Ma, Ying Bao, Fei Li, Qiuxiang Yin, Hongxun Hao   +9 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Effects of Synthesis Parameters on Crystallization Behavior of K-MER Zeolite and Its Morphological Properties on Catalytic Cyanoethylation Reaction [PDF]

, 2020
MER-type zeolite is an interesting microporous material that has been widely used in catalysis and separation. By carefully controlling the synthesis parameters, a procedure to synthesize K-MER zeolite crystals with various morphologies has been ...
Ying-Wai Cheong, Boon Seng Ooi, Fitri Khoerunnisa, Tau Chuan Ling, Eng-Poh Ng, Ka-Lun Wong   +5 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source