Results 61 to 70 of about 356,339 (309)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Rapid Quantification of Low-Level Crystalline Impurities in Dalmelitinib Mesylate Using NIR Spectroscopy and Chemometric Modeling

Separations
Accurate measurement and control of impurities are critical for ensuring the quality and therapeutic performance of solid-state pharmaceutical formulations. This study introduces a rapid, minimal sample preparation analytical approach for quantifying low-
Runxi Gui, Xiaogang Lian, Maolin Li, Mingdi Liu, Lina Zhou, Songgu Wu, Qiuxiang Yin   +6 more
doaj   +1 more source

Solution-Mediated Polymorphic Transformation of L-Carnosine from Form II to Form I

Crystals, 2022
In this study, L-carnosine was chosen as the model compound to systematically study solution-mediated polymorphic transformation by online experiment and theoretical simulation.
Yanan Zhou, Shuyi Zong, Jie Gao, Chunsong Liu, Ting Wang   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Formation Mechanism of the Crystal Morphology of Guanidinoacetic Acid: Selective Adsorption of Additives and Solute Diffusion

Separations
Guanidinoacetic acid (GAA), an important feed additive, shows poor powder properties due to its morphological characteristics. In this study, GAA was employed as a model compound to investigate the regulatory effects of polymeric additives (hydroxypropyl
Xin Chen, Yifan Li, Qian Wu, Ting Wang, Na Wang, Lina Zhou, Hongxun Hao, Jingkang Wang   +7 more
doaj   +1 more source

Population Balance and CFD Simulation of Particle Aggregation and Growth in a Continuous Confined Jet Mixer for Hydrothermal Synthesis of Nanocrystals

Crystals, 2021
Population balance and computational fluid dynamics models are built and integrated to carry out a simulation study of the reactive crystallisation process in a confined jet mixer (CJM) for the continuous flow synthesis of TiO2 nanoparticles at a ...
Qing Yun Li, Xue Zhong Wang
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

BIWIC 2022 : 27th International workshop on industrial crystallization : 31 August – 2 September, 20022, Aalto University, Finland

, 2022
The 27th International Workshop on Industrial Crystallization (BIWIC 2022) was hosted at Aalto University as an in-person event after a two-year delay due to the COVID-19 pandemic.
Louhi-Kultanen, Marjatta (editor), Ila, Mitra (editor)   +1 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source