Results 111 to 120 of about 224,062 (299)

Domino Synthesis of Functionalized Cyclic Acetals From Organic Carbonates

Advanced Synthesis &Catalysis, EarlyView.
Cyclic carbonates equipped with acrylic functional groups are shown to undergo a domino process in the presence of a suitable alkoxide to deliver novel types of decorated cyclic acetals. The developed protocol combines practical conditions and a wide scope and features a new reactivity modus for these carbon dioxide‐derived heterocyclic precursors.
Natalia Kulbacka, Wangyu Shi, Sophie M. Guillaume, Jean‐François Carpentier, Jordi Benet‐Buchholz, Arjan W. Kleij   +5 more
wiley   +1 more source

Data acquisition and analysis software at the Swiss Light Source macromolecular crystallography beamlines [PDF]

, 2016
J.A. Wojdyla, Ezequiel Panepucci, Jakub W. Kamiński, Simon Ebner, Xiaoqiang Wang, José Gabadinho, Meitian Wang   +6 more
openalex   +1 more source

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

Sostenibilità e design del gioiello

And
La ricerca affronta il tema del design del gioiello in un’ottica di sostenibilità ambientale e sociale relativa tanto ai materiali preziosi utilizzati quanto ai processi produttivi impiegati.
Alessandra Avella, Nicola Pisacane
doaj  

Martensite crystallography and chemistry in dual phase and fully martensitic steels

, 2018
Cheng-Ran Du, J.P.M. Hoefnagels, Sebastian Kölling, M.G.D. Geers, Jilt Sietsma, Roumen Petrov, Vitaliy Bliznuk, P. M. Koenraad, D. Schryvers, Behnam Amin-Ahmadi   +9 more
openalex   +2 more sources

Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers

, 2020
A. Dolbois, Laurent Batiste, L. Wiedmer, Jing Dong, Manuela M. Brütsch, Danzhi Huang, Nicholas Deerain, Dimitrios Spiliotopoulos, Iván Cheng‐Sánchez, Eleen Laul, Cristina Nevado, P. Sledz, Amedeo Caflisch   +12 more
openalex   +2 more sources

Crystallography Platform at the Pasteur Institute [PDF]

, 2016
Ahmed Haouz, Patrick Weber, Cédric Pissis, Rafael Navaza, Frederick Saul   +4 more
openalex   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Evaluation of docking programs for predicting binding of Golgi α‐mannosidase II inhibitors: A comparison with crystallography

, 2007
Pablo Englebienne, Hélène Fiaux, D.A. Kuntz, Christopher R. Corbeil, Sandrine Gerber‐Lemaire, David R. Rose, Nicolas Moitessier   +6 more
openalex   +2 more sources

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source