Results 121 to 130 of about 224,062 (299)

First crystallography experiments at the European XFEL [PDF]

, 2018
M. Messerschmidt
openalex   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Slow cooling and temperature-controlled protein crystallography

, 2009
Matthew Warkentin, Robert Thorne
openalex   +1 more source

Electron crystallography greatly expands organic and inorganic X-ray crystal structure determination [PDF]

, 2018
Tim Gruene
openalex   +1 more source

A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme

Advanced Science, EarlyView.
The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun, Chao Dou, Weizhu Yan, Pengpeng Chen, Lu Zhang, Dan Zhou, Yanhui Zheng, Zhaolin Long, Shoujie Li, Xiaoqing Xu, Qiuxia Huang, Xiaofeng Zhu, Wei Cheng   +12 more
wiley   +1 more source

MicroED: Unveiling the Structural Chemistry of Plant Biomineralisation

Molecules
Plants are able to produce various types of crystals through metabolic processes, serving functions ranging from herbivore deterrence to photosynthetic efficiency.
Damian Trzybiński, Marcin Ziemniak, Barbara Olech, Szymon Sutuła, Tomasz Góral, Olga Bemowska-Kałabun, Krzysztof Brzost, Małgorzata Wierzbicka, Krzysztof Woźniak   +8 more
doaj   +1 more source

Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes

Advanced Science, EarlyView.
Mid‐infrared photothermal microscopy enables label‐free structural, molecular, and functional imaging of protein aggregates in astrocyte cells. The processes of astrocytes differentiated on a nanomaterial interface are characterized by α‐helical signatures combined with enhanced interfacial thermal resistance properties, while the cell soma of non ...
Panagis D. Samolis, Chiara Lazzarini, Rahmetullah Durgun, Barbara Barile, Giorgia Conte, Tamara Posati, Marco Caprini, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander   +9 more
wiley   +1 more source

Crystallographer's Challenge in the 21st Century. 4. Environmental Crystallography. Crystallography of Radioactive Waste Disposal for the Human Future.

, 2001
Katsuyuki Kawamura
openalex   +2 more sources

Pump-Probe Time-Resolved Serial Femtosecond Crystallography at SACLA: Current Status and Data Collection Strategies [PDF]

, 2019
Eriko Nango, Minoru Kubo, Kensuke Tono, So Iwata   +3 more
openalex   +1 more source

Atomic‐Scale Insights into Yttrium‐Induced Grain Boundary Structure Modification in Al2O3

Advanced Science, EarlyView.
Using advanced STEM characterization combined with NNP‐based MCMD calculations, it is revealed that Y segregation at ∑13 Al2O3 GB involves not only simple substitution of Y for Al atoms but also structural adaptation with a change in GB atomic density, leading to minimized excess volume and lowest GB energy.
Jingyuan Yan, Tatsuya Yokoi, Yuuki Nakano, Shun Kondo, Bin Feng, Naoya Shibata, Katsuyuki Matsunaga, Yuichi Ikuhara   +7 more
wiley   +1 more source