Results 161 to 170 of about 415,174 (326)
Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization
Advanced Science, EarlyView.Molecular glues that stabilize protein–protein interactions are challenging to identify. Here, hydrogen‐deuterium exchange mass spectrometry can show and reveal gluing mechanisms that vary between protein binding partners. Abstract Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions.
Danielle F. Kay +3 more
wiley +1 more source
Dimer‐Specific FokT‐seq Reveals DNA‐Binding Dimerization and Novel Genomic Targets of TDP‐43
Advanced Science, EarlyView.Loss of TDP‐43 dimerization is implicated in ALS, yet its mechanistic role remains elusive. This study introduces FokT, a novel system that restores TDP‐43 dimerization to map its DNA targets via FokT‐seq. The findings uncover key binding sites and offer a versatile tool for exploring dimer‐dependent transcriptional regulation.
Mingming Yang +4 more
wiley +1 more source
CCVII. On crystallography, with a description of a new goniometer and crystallonome [PDF]
H. B. Leeson
openalex +1 more source
Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities
Advanced Science, EarlyView.The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley +1 more source
Crystallography for Beginners, with an Appendix on the use of the Blowpipe and the Determination of Common Minerals (after the method of Dr Albin Weisbach) [PDF]
, 1896 openalex +1 more source
Biomolecular Interaction Prediction: The Era of AI
Advanced Science, EarlyView.This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley +1 more source
Binary nickel alloy phase diagrams compilation and critical evaluation [PDF]
Equilibrium diagrams general features, intermediate phases, liquidus and solidus, terminal solid solutions, metastable phases, crystallography, and thermodynamics are ...
Hontas, J.
core +1 more source
Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi
Advanced Science, EarlyView.The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda +12 more
wiley +1 more source