Results 51 to 60 of about 415,174 (326)

Crystallography for the People [PDF]

Acta Crystallographica Section A Foundations and Advances, 2013
The British Crystallographic Association (BCA) has engaged in public outreach projects over the past two years, aimed at communicating the basic principles and applications of crystallography to the general public, especially in light of the Bragg Centenary Celebrations and the International Year of Crystallography.
Lynne H. Thomas, Claire A. Murray, Anna J. Warren   +2 more
openaire   +3 more sources

Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing

Bioinorganic Chemistry and Applications
Alzheimer’s disease (AD) is the most common neurodegenerative disorder associated with cognitive decline and loss of memory. It is postulated that the generation of reactive oxygen species (ROS) in Fenton-like reaction connected with Cu(II)/Cu(I) redox ...
Marianna Flora Tomasello, Maria Carmela Di Rosa, Irina Naletova, Michele Francesco Maria Sciacca, Alessandro Giuffrida, Giuseppe Maccarrone, Francesco Attanasio   +6 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Combinatorial problems of (quasi-)crystallography

, 2002
Several combinatorial problems of (quasi-)crystallography are reviewed with special emphasis on a unified approach, valid for both crystals and quasicrystals. In particular, we consider planar sublattices, similarity sublattices, coincidence sublattices,
Baake, Michael, Grimm, Uwe
core   +3 more sources

X-Ray Diffraction under Extreme Conditions at the Advanced Light Source

Quantum Beam Science, 2018
The more than a century-old technique of X-ray diffraction in either angle or energy dispersive mode has been used to probe materials’ microstructure in a number of ways, including phase identification, stress measurements, structure solutions, and the ...
Camelia V. Stan, Christine M. Beavers, Martin Kunz, Nobumichi Tamura   +3 more
doaj   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Distinguishing Biologically Controlled Calcareous Biomineralization in Fossil Organisms Using Electron Backscatter Diffraction (EBSD)

Frontiers in Earth Science, 2018
Although carbonate-precipitating cyanobacteria are ubiquitous in aquatic ecosystems today, the criteria used to identify them in the geological record are subjective and rarely testable.
Jan-Filip Päßler, Emilia Jarochowska, Michel Bestmann, Axel Munnecke   +3 more
doaj   +1 more source

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae

FEBS Open Bio, EarlyView.
A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima   +7 more
wiley   +1 more source

Point groups in crystallography [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2008
Two dual spaces are extensively used in crystallography: the point space E n , hosting the crystal pattern; and the vector space V n , where face normals and reciprocal-lattice vectors are defined. The term "point group" is used in crystallography to indicate four different types of groups in these two spaces.
Nespolo, Massimo, Souvignier, B.
openaire   +7 more sources

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source