Results 221 to 230 of about 74,543,549 (272)

The epigenetic landscape of skeletal muscle in response to exercise and aging

open access: yesThe FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Real‐world evidence on the safety and effectiveness of thrombopoietin receptor agonists in aplastic anaemia: A descriptive study using Japanese hospital administrative data

open access: yes
British Journal of Haematology, EarlyView.
Kayoko Mizuno   +6 more
wiley   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach   +2 more
wiley   +1 more source

Current State of Moderate Congenital Haemophilia A and the Need for Preventive Treatment

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction The severity of haemophilia A is classified by the degree of factor VIII (FVIII) deficiency, rather than by clinical manifestations. However, FVIII activity alone does not necessarily accurately reflect clinical severity such as bleeding tendency, and patients with mild‐to‐moderate haemophilia A can experience significant disease ...
Masahiro Takeyama   +6 more
wiley   +1 more source

Spinal Muscle Health in Chronic Low Back Pain: An Integrated Narrative Review of Muscle Quality, Function, and Clinical Implications. [PDF]

open access: yesBioengineering (Basel)
Rossi M   +9 more
europepmc   +1 more source

Colluding With Perpetrators? A Content Analysis of Judicial Explanations for Child Sexual Abuse Perpetration

open access: yesThe Howard Journal of Crime and Justice, EarlyView.
ABSTRACT Documenting how judges explain child sexual abuse (CSA) perpetration is an important task as sentencing decisions are informed by their explanatory understandings. Despite this, the research into judges’ explanations for CSA perpetration is piecemeal and dated.
Kelly Richards
wiley   +1 more source

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