Results 241 to 250 of about 74,543,549 (272)

Successful Management of Persistent DRESS with Tofacitinib: Two Case Reports

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Marc Hernández‐Santacana, Ignasi Martí‐Martí, Victoria Amat‐Samaranch, Irene Fuertes de Vega, Priscila Giavedoni, José M. Mascaró Jr   +5 more
wiley   +1 more source

Sternocleidomastoid muscle morphology is independently associated with neck strength and endurance in athletes and para-athletes. [PDF]

Front Physiol
Rozenstoka S, Comadran de Barnola E, Kauzena S, Akuratere G, Galeja Z, Deicmane D.   +5 more
europepmc   +1 more source

Investigation of the in Vitro Antifungal and Antibiofilm Activities of Ceragenins CSA-8, CSA-13, CSA-44, CSA-131, and CSA-138 Against Candida Species

Diagnostic Microbiology and Infectious Disease, 2018
Cationic steroid antimicrobials (CSA-ceragenin) are a new class of antimicrobial agent. In vitro activities of CSA-8, CSA-13, CSA-44, CSA-131, and CSA-138 and amphotericin B (AMP-B) were assessed against 50 nonrepeat Candida spp.
Paul B Savage, Mayram Hacıoğlu, Çağla Bozkurt-Güzel   +2 more
exaly   +4 more sources

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Ceragenin CSA-13 Exhibits Antimicrobial Activity Against Cariogenic and Periodontopathic Bacteria

Oral Microbiology and Immunology, 2009
Introduction:  Ceragenin CSA‐13 is a bile‐acid‐based mimic of endogenous antimicrobial peptides and shares a mechanism of action with many of these antimicrobial agents. Because CSA‐13 is not peptide based, it is not a substrate for the proteases that are found in the oral cavity, which are capable of degrading antimicrobial peptides.
Paul B Savage, E Isogai
exaly   +3 more sources

Activities of Ceragenin CSA-13 Against Established Biofilms in an In Vitro Model of Catheter Decolonization

Anti-Infective Agents in Medicinal Chemistry, 2009
Bacterial biofilms on medical devices are a primary source of infection, and efforts have been made to develop means of decontaminating colonized devices including hemodialysis catheter "lock" solutions. Because bacterial biofilms are inherently resistant to many antibiotics and widespread use of antibiotics contributes to resistance development, there
Jacob Pollard, Jon Wright, Yanshu Feng, Dianliang Geng, Carl Genberg, Paul Savage   +5 more
openaire   +1 more source

Effects of the microbicide ceragenin CSA‐13 on and properties ofBacillus subtilisspores prepared on two very different media

Journal of Applied Microbiology, 2019
To determine how the microbicide ceragenin-13 (CSA-13) kills Bacillus subtilis spores prepared on growth or sporulation media, and these spores' properties.Spores made on Luria broth (LB) growth or double-strength Schaeffer's-glucose (2xSG) sporulation plates found that spores made on LB plates have coat defects as evidenced by their lower hypochlorite
S. Ghosh, G. Joseph, G. Korza, L. He, J.‐H. Yuan, W. Dong, B. Setlow, Y.‐Q. Li, P.B. Savage, P. Setlow   +9 more
openaire   +2 more sources

Potential synergy activity of the novel ceragenin, CSA-13, against clinical isolates of Pseudomonas aeruginosa, including multidrug-resistant P. aeruginosa

Journal of Antimicrobial Chemotherapy, 2007
Previous data from our research had shown that the novel ceragenin, CSA-13, demonstrated concentration-dependent bactericidal activity against glycopeptide-resistant Staphylococcus aureus. However, it is unknown whether CSA-13 demonstrates a similar property against Pseudomonas aeruginosa.
Judy N, Chin, Ronald N, Jones, Helio S, Sader, Paul B, Savage, Michael J, Rybak   +4 more
openaire   +2 more sources

Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells

Anti-Cancer Drugs, 2013
Antimicrobial peptides of the cathelicidin family play a central role in the host defense system. Our group has reported previously that cathelicidin-related or cathelicidin-modified antimicrobial peptides, such as FF/CAP-18, have antiproliferative effects on the squamous cell carcinoma cell line SAS-H1 and colon cancer-derived cell line HCT116 ...
Kengo, Kuroda, Tomokazu, Fukuda, Kazuhiko, Okumura, Hiroshi, Yoneyama, Hiroshi, Isogai, Paul B, Savage, Emiko, Isogai   +6 more
openaire   +2 more sources

CSA-13 treatment in a murine model of Pseudomonas pneumonia-induced sepsis and its effects on renal injury, inflammation, and glycocalyx derangement

The Journal of Antibiotics
Pneumonia-induced sepsis is a major cause of acute kidney injury (AKI), which can lead to high morbidity and mortality. Ceragenins, such as CSA-13, are synthetic mimics of antimicrobial peptides with known antimicrobial and immunomodulatory properties.
Ugur Aksu, Cagla Bozkurt-Guzel, Gonca Erkose-Genc, Olgu Enis Tok, Mukaddes Esrefoglu, Ozlem Oyardi, Paul B. Savage   +6 more
openaire   +2 more sources