Results 51 to 60 of about 37,852,591 (164)

In vitro activity of ceragenins against Burkholderia cepacia complex

, 2022
Burkholderia cepacia complex (Bcc) species are aerobic, Gram-negative and non-fermantative bacilli. Bcc can cause clinical symptoms in patients with cystic fibrosis, ranging from asymptomatic carriage to fatal pneumonia.
Bozkurt-Guzel, Cagla, Savage, P. B., Demir, Elif Sena, Altay, Özlem,, Savage, Paul B, Oyardi, O., Savage, Paul B., Bozkurt-Guzel, C., Oyardi, Ozlem, Altay, Havva Ozlem, Demir, E. S., Havva Ozlem Altay, Ozlem Oyardi, Elif Sena Demir, Paul B. Savage, Cagla Bozkurt-Guzel   +15 more
core   +1 more source

Evaluation of Cytotoxicity, Antimicrobial, and Antifungal Properties of Ceragenins CSA-44 and CSA-131

Abstract A novel family of antimicrobial drugs is known as cationic steroid antimicrobials (CSA-ceragenin), which includes CSA44 and CSA 131. This work aimed to examine the antibacterial and antimycotic properties of CSA44 and CSA 131 against Staphylococcus aureus, methicillin-resistant S.
Kubra Aslantas, Cihan Oz, Ali Taghizadehghalehjoughi, Sidika Genc, Aziz Sahin Erdogan, Paul B. Savage, Mehmet Cemal Adiguzel   +6 more
openaire   +1 more source

Myeloablative Busulfan, Fludarabine and Melphalan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Childhood Myeloid Malignancy

Asia-Pacific Journal of Clinical Oncology, EarlyView.
We report our single‐center experience of transplant outcomes with a busulfan, fludarabine and melphalan‐based conditioning regimen for children < 18 years of age. The regimen was shown to be well tolerated and effective for heavily pretreated children with high‐risk myeloid malignancies prior to allogeneic hematopoietic stem cell transplant.
Mayank Dhamija, Fiona Kerr, Hazel Gough, Johnathan Soggee, Laurence C. Cheung, Rishi S. Kotecha, Shanti Ramachandran   +6 more
wiley   +1 more source

Renal oxygenation, function and histopathology in an ovine model of heart failure undergoing cardiopulmonary bypass with 48 hours of recovery: a prospective, observational study*

Anaesthesia, EarlyView.
Summary Introduction Acute kidney injury is common after cardiac surgery requiring cardiopulmonary bypass, yet preventive strategies are limited. Progress has been hindered by a lack of clinically relevant experimental models incorporating pre‐existing heart disease.
Anton L. Trask‐Marino, Bruno Marino, Taku Furukawa, Lachlan F. Miles, Jai Raman, Andrew D. Cochrane, Peter R. McCall, Terase F. Lancefield, Roger G. Evans, Ian E. Birchall, Alemayehu H. Jufar, Ashenafi Betrie, Lars I.P. Snel, Munenori Kusunoki, Sally G. Hood, Linda Cornthwaite, Bruce Treagus, Connie Pei Chen Ow, Lindsea C. Booth, Clive N. May, Yugeesh R. Lankadeva   +20 more
wiley   +1 more source

Santé mentale et bien-être pour les étudiants du postsecondaire

, 2020
Document available for free on CSA Group's website for residents of Canada.Disponible en français dans EDUQ.info sous le titre "Santé mentale et bien-être pour les étudiants du postsecondaire"

core   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Synergistic Activity of Ceragenins Against Carbapenem-Resistant Acinetobacter baumannii Strains in Both Checkerboard and Dynamic Time-Kill Assays

, 2020
Acinetobacter baumannii is an emerging opportunistic pathogen that primarily infects critically ill patients in nosocomial settings and there is a need for identifying new alternative therapeutic agents against these organisms. Ceragenins are non-peptide,
Bozkurt-Guzel, Cagla, Inci, Gozde, OYARDI, ÖZLEM, Savage, Paul B.   +3 more
core   +2 more sources

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Supplementary Figures - Targeting bacteria causing otitis media using nanosystems containing non-spherical gold nanoparticles and ceragenins

, 2021
Supplementary Figure 1. FT-Raman spectra of MHDA (black curve, powder), AuP NPs after synthesis (pink curve, solution), CSA-13 (red curve, solution), CSA-44 (blue curve, solution) and CSA-131 (green curve, solution) Supplementary Figure 2. TGA results of
Suhanya V. Prasad (11759632), Tamara Daniluk (6856400), Urszula Wnorowska (2836901), Łukasz Suprewicz (11759638), Robert Bucki (487742), Ewelina Piktel (2836883), Krzysztof Fiedoruk (729675), Magdalena Parlińska-Wojtan (11759646), Jakub Spałek (11759641), Alexey Maximenko (11759635), Joanna Depciuch (11759634), Sławomir Okła (11759649), Piotr M. Zielinski (11759643), Paul B. Savage (178014)   +13 more
core   +1 more source

Insights into the chemical basis for the impact of ceragenin and derivative compounds on the mechanical performance of medical adhesive formulations

Discover Applied Sciences
An approach to reducing and preventing surgical site infections (SSI) is to incorporate an antimicrobial compound into the formulation of medical adhesives.
Shane M. Drake, Caleb D. Potter, Aaron L. Zaugg, Melissa N. Lumogdang, Daniel J. Pendleton, Jacob R. Orchard, Paul B. Savage, James E. Patterson   +7 more
doaj   +1 more source