Results 31 to 40 of about 521,531 (302)

A comparative cross sectional study of social capital among primary caregivers of children with disabilities in rural Bangladesh

Discover Public Health
Aim To describe the social capital of primary caregivers of children with disability in rural Bangladesh. Method A cross-sectional comparative study was conducted with children (
Manik Chandra Das, Israt Jahan, Rosalie Power, Mahmudul Hassan Al Imam, Genevieve Perrins, Shafiul Islam, Delwar Akbar, Mohammad Muhit, Nadia Badawi, Gulam Khandaker   +9 more
doaj   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

Methotrexate-associated biochemical alterations in a patient with chronic neurotoxicity [PDF]

Journal of Medical Biochemistry, 2009
Intrathecal and/or high-dose intravenous administration of methotrexate (MTX) in the treatment of malignancies such as acute lymphoblastic leukaemia (ALL) has been associated with cases of mild to severe neurotoxicity.
Vezmar Sandra, Bode Udo, Jaehde Ulrich
doaj  

DataSheet_1_Integrated transcriptomic and metabolomic analysis reveals the metabolic programming of GM-CSF- and M-CSF- differentiated mouse macrophages.docx

, 2023
Macrophages play a critical role in the inflammatory response and tumor development. Macrophages are primarily divided into pro-inflammatory M1-like and anti-inflammatory M2-like macrophages based on their activation status and functions.
Qiaoling Song (365087), Chenyang Zhao (533763), Danling Gao (12242708), Guanghui Zhao (142408), Qianyue Zhang (10901007), Yuting Xu (4483672), Peizhe Lu (15288049), Lihong Wu (1666963), Shan Liu (193759), Yuantao Liu (9624686), Jinbo Yang (220579)   +10 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

CSF-1 as a regulator of macrophage activation and immune responses [PDF]

, 2003
Macrophage activation is a key determinant of susceptibility and pathology in a variety of inflammatory diseases. The extent of macrophage activation is tightly regulated by a number of pro-inflammatory cytokines (e.g.
Sweet, MJ, Sweet, Matthew J, Hume, David A, Hume, DA   +3 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Enterovirus Detection in Patients Suspected Aseptic Meningitis by RT-PCR in Kermanshah, Iran [PDF]

Journal of Kerman University of Medical Sciences, 2018
Background: Aseptic meningitis is frequently caused by viral agents, particularly human enterovirus. Several methods of Reverse Transcription PCR(RT-PCR) have recently been introduced and modified for better diagnosis of enteroviral infection in ...
Alisha Akya, Azam Elahi, Mohsen Moghoofei, Roya Chegenelorestani, Ahmad Nejati, Farhad Babaei   +5 more
doaj  

Liquid biopsy in CNS tumors: Current status & future perspectives

Indian Journal of Pathology and Microbiology, 2022
Precise classification of central nervous system (CNS) malignancies is vital for the treatment and prognostication. Identification of noninvasive markers can be of importance to guide treatment decisions and in monitoring treatment response.
Nuzhat Husain, Adil Husain, Sridhar Mishra, Pallavi Srivastava   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source