Results 141 to 150 of about 1,649,172 (225)
Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 3, September 2026.Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao +8 more
wiley +1 more source
Liquid biopsy in non-small cell lung cancer: clinical impact and innovative applications
openPresupposti: Il tumore polmonare non a piccole cellule è stata la prima neoplasia solida in cui la biopsia liquida è stata approvata per valutare le mutazioni del gene codificante per il recettore del fattore di crescita epidermico (EGFR).
SCAGLIOSO, MATTEO
core
Clinical trial status of exosomes‐based cancer theranostics
Clinical and Translational DiscoveryExosomes, are a subpopulation of extracellular vesicles, that originate from endosomes. The major role of exosomes is cellular communication (in this process exosomes display the status of the parental cell's nature, healthy or the cell suffers any ...
Swarup Sonar
doaj +1 more source
Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, Volume 59, Issue 9, September 2026.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
Signal Transduction and Targeted TherapyImmune checkpoint blockade (ICB) has revolutionized cancer treatment, but the therapeutic response is highly heterogeneous, which highlights the necessity for developing predictive biomarkers and overcoming ICB resistance. Cancer cell-intrinsic features,
Yufeng Guo +9 more
doaj +1 more source
International Journal of Urology, Volume 33, Issue 9, September 2026.ABSTRACT Objective The aim of this study was to perform a comprehensive characterization of CTSV regulation in bladder cancer (BC) and its association with clinicopathological features, prognosis, and tumor stroma modulation using multi‐omics databases.
Wallax Augusto Silva Ferreira +5 more
wiley +1 more source
LifeDue to their clinical heterogeneity, nonspecific symptoms, and the limitations of existing biomarkers and imaging modalities, metabolic brain diseases (MBDs), such as mitochondrial encephalopathies, lysosomal storage disorders, and glucose metabolism ...
Kyle Sporn +7 more
doaj +1 more source
The Emerging Role of UCHL1 in Neurological and Musculoskeletal Diseases
Immunology &Cell Biology, Volume 104, Issue 8, Page 783-793, September 2026.UCHL1‐associated pathology. The pathological role of UCHL1 in multisystem diseases, including cancer, neurological, musculoskeletal and cardiovascular disorders. ABSTRACT Ubiquitin C‐terminal hydrolase L1 (UCHL1) is a highly conserved deubiquitinating enzyme that has transitioned from being viewed as a “brain‐specific” protein to a global regulator of ...
Ru Feng +3 more
wiley +1 more source