Results 121 to 130 of about 10,378 (206)

PATH-66. Double identity: molecular heterogeneity between liquid biopsy from the CSF and tissue samples of a multifocal, disseminated High-Grade Astrocytoma with Piloid Features (HGAP) in NF1 patient

Neuro-Oncology
Abstract We describe a 46-year-old male with Neurofibromatosis type 1 (NF1) and a previously known parenchymal medullary mass identified in 2022, initially managed with surveillance. In late 2023, he developed a progressive brainstem syndrome prompting presentation to our center.
Dweik, Khaled, Mrugala, Maciej, Harahsheh, Ehab, Donev, Kliment, Ashman, Jonathan, Bendok, Bernard, Ensign, Shannon Fortin   +6 more
openaire   +1 more source

Minimally invasive liquid biopsy analysis of B-cell non-Hodgkin lymphomas [PDF]

, 2018
The gold standard for the diagnosis of tumors are tissue biopsies. However, sometimes it is not feasible to obtain a tissue biopsy due to a high risk of complications or difficult anatomical localizations.
Jiwa, L.S.
core  

The potential of liquid biopsy for detection of the KIAA1549-BRAF fusion in circulating tumor DNA from children with pilocytic astrocytoma [PDF]

Background Low-grade gliomas (LGGs) represent children’s most prevalent central nervous system tumor, necessitating molecular profiling to diagnose and determine the most suitable treatment.
Arthur, Cecilia, Jylhä, Cecilia,, Krynina, Olha,, Sandgren, Johanna,, Jylhae, Cecilia,, Díaz de Ståhl, Teresita,, Jylhae, Cecilia, Giraud, Geraldine,, Tham, Emma,, Tham, Emma, Sandvik, Ulrika,, Díaz de Ståhl, Teresita, Fritzberg, Anders, Fritzberg, Anders,, Sandgren, Johanna, de Stahl, Teresita Diaz, Giraud, Geraldine, Nyman, Per,, de Stahl, Teresita Diaz,, Krynina, Olha, Jylhä, Cecilia, Arthur, Cecilia,, Nyman, Per, Sandvik, Ulrika   +23 more
core   +1 more source

Clinical trial status of exosomes‐based cancer theranostics

Clinical and Translational Discovery
Exosomes, are a subpopulation of extracellular vesicles, that originate from endosomes. The major role of exosomes is cellular communication (in this process exosomes display the status of the parental cell's nature, healthy or the cell suffers any ...
Swarup Sonar
doaj   +1 more source

BIOM-56. A FEASIBILITY STUDY UTILIZING SEQUENTIAL CEREBROSPINAL FLUID (CSF) - BASED LIQUID BIOPSY AND AMIDE PROTON TRANSFER (APT) MRI TO DIFFERENTIATE DISEASE PROGRESSION FROM RADIATION NECROSIS IN PATIENTS WITH BRAIN METASTASIS FROM SOLID TUMORS

Neuro-Oncology
Abstract BACKGROUND Brain metastases affect 30–40% of patients with solid tumors, and as systemic therapies improve survival, intracranial recurrences are more common. Radiation therapy is standard of care treatment but can frequently lead to radiation necrosis, which can mimic tumor ...
Maia, MD, Catarina Martins, Jiang, MD, PhD, Shanshan, Kut, MD, PhD, Carmen, Croog, MD, Victoria Jane, Scott, MD, Susan, Levy, MD, Benjamin, Wilkinson, MD, Mary, Sheng, MD, Jennifer Y, Mark-Adjeli, MD, Princess, Santa-Maria, MD, MSCI, Cesar A, Kamson, MD, PhD, David, Bettegowda, MD, PhD, Chetan, Sahebjam, MD, Solmaz   +12 more
openaire   +2 more sources

Targeting tumor-intrinsic S100 calcium-binding protein A1 augments antitumor immunity and potentiates immunotherapy efficacy

Signal Transduction and Targeted Therapy
Immune checkpoint blockade (ICB) has revolutionized cancer treatment, but the therapeutic response is highly heterogeneous, which highlights the necessity for developing predictive biomarkers and overcoming ICB resistance. Cancer cell-intrinsic features,
Yufeng Guo, Rui Wan, Jianchun Duan, Li Yuan, Zhijie Wang, Jia Zhong, Xue Zhang, Zixiao Ma, Hua Bai, Jie Wang   +9 more
doaj   +1 more source

Epigenetic Profiling of Cell-Free DNA in Cerebrospinal Fluid: A Novel Biomarker Approach for Metabolic Brain Diseases

Life
Due to their clinical heterogeneity, nonspecific symptoms, and the limitations of existing biomarkers and imaging modalities, metabolic brain diseases (MBDs), such as mitochondrial encephalopathies, lysosomal storage disorders, and glucose metabolism ...
Kyle Sporn, Rahul Kumar, Kiran Marla, Puja Ravi, Swapna Vaja, Phani Paladugu, Nasif Zaman, Alireza Tavakkoli   +7 more
doaj   +1 more source

ID #1131 Predicting Early Tumor Progression in Patients with Atypical Teratoid/Rhabdoid Tumor with Longitudinal CSF Liquid Biopsies: A Report from Phase 2 Study (SJATRT) stratum B1.

Neuro-Oncology Pediatrics
Abstract Background Atypical teratoid/rhabdoid (AT/RT) is an aggressive pediatric brain tumor, prevalent in children < 3 years(Y) of age; methylation profiles subclassify AT/RTs into AT/RT-MYC (MYC), AT/RT-SHH (SHH), and AT/RT-TYR (TYR). At the molecular level, AT/RT shows alterations in
Aditi Bagchi, Anna Kostecka, Santhosh Upadhyaya, Catherine Billups, Sandeep Dhanda, Kyle S Smith, Taha Soliman, Patricia Baxter, Anne Bendel, Dolly Aguilera, Lindsay Kilburn, John Crawford, Sonia Partap, Emily Hanzlik, Quynh Tran, Alex Breuer, Wenjie Qi, Congyu Lu, Anjali Singh, Miya Richardson, Eroica Soans, Paul Klimo, Xin Zhou, Brent Orr, Thomas Merchant, Giles Robinson, Arzu Onar-Thomas, Paul Northcott, Amar Gajjar   +28 more
openaire   +1 more source

Case Report: Proteomic analysis of cerebrospinal fluid in a retinoblastoma patient

Frontiers in Oncology
This study focuses on the proteomic analysis of cerebrospinal fluid (CSF) in a patient with stage III retinoblastoma (RB) with the aim to identify molecular changes associated with central nervous system (CNS) relapse.
Angela Galardi, Virginia Di Paolo, Chiara Lavarello, Ida Russo, Antonino Romanzo, Evelina Miele, Rita De Vito, Daniela Longo, Andrea Petretto, Franco Locatelli, Franco Locatelli, Angela Di Giannatale   +11 more
doaj   +1 more source

Targeted multiplex validation of CSF proteomic biomarkers: implications for differentiation of PCNSL from tumor-free controls and other brain tumors [PDF]

IntroductionPrimary central nervous system lymphoma (PCNSL) is a rare type of non-Hodgkin’s lymphoma that affects brain parenchyma, eyes, cerebrospinal fluid, and spinal cord. Diagnosing PCNSL can be challenging because imaging studies often show similar
Mengxue Zhang, Bobin Chen, Karl G. Sylvester, Yaqi Zhang, Yan Ma, Seema Nagpal, James Schilling, Qiming Tang, Qing Li, Zhi Han, Xuefeng B. Ling, Yunan Lin, Yun Ding, Yufeng Qian, Bo Jin, C. James Chou, Zhiguang Lin, Doff B. McElhinney, Ruben Y. Luo, Wei-Li Liao, Sheeno Thyparambil, Jingjing Ma   +21 more
core   +1 more source