Results 111 to 120 of about 10,378 (206)

Liquid biopsy for evaluating mutations and chromosomal aberrations in cerebrospinal fluid from patients with primary or metastatic CNS tumors [PDF]

Background: Cytopathology analysis of cerebrospinal fluid (CSF) is limited in detecting tumors in patients with suspected primary or metastatic central nervous system (CNS) malignancy.
Andrew Ip, Maher Albitar, Sally Agersborg, Andre Goy, Ahmad Charifa, Arash Mohtashamian   +5 more
core   +1 more source

Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients [PDF]

, 2017
Background: RNAs within extracellular vesicles (EVs) have potential as diagnostic biomarkers for patients with cancer and are identified in a variety of biofluids. Glioblastomas (GBMs) release EVs containing RNA into cerebrospinal fluid (CSF).
Carter, Bob S, Frederick F Lang, Chen, Clark, E Antonio Chiocca, Chetan Bettegowda, Lori LoGuidice, Clark Chen, Fred Hochberg, Breakefield, Xandra, Ricardo Komotar, Emily Berghoff, Curry, William, Andrew Parsa, Parsa, Andrew, Linda Liau, Xandra Breakefield, Randy Jensen, Florian Ringel, Li, Hongying, Akers, Johnny, LoGuidice, Lori, Johnny Akers, Hochberg, Fred, Lang, Frederick F, Figueroa, Javier M, Bob S Carter, Kalkanis, Steven, Hongying Li, Ringel, Florian, Kim, Ryan, Kalkanis, Steven N, Johan Skog, Skog, Johan, Liau, Linda, Cahill, Daniel, William Curry, Thompson, Reid, Daniel Cahill, Reid Thompson, Henson, John, Javier M Figueroa, Chiocca, E A, Steven Kalkanis, Jensen, Randy, Isaac Yang, Bettegowda, Chetan, Ryan Kim, Berghoff, Emily, Messer, Karen, Yang, Isaac, Karen Messer, Komotar, Ricardo, Chiocca, E Antonio, John Henson   +53 more
core   +1 more source

New Frontiers in Diagnosis and Therapy of Circulating Tumor Markers in Cerebrospinal Fluid In Vitro and In Vivo

Cells, 2019
One of the greatest challenges in neuro-oncology is diagnosis and therapy (theranostics) of leptomeningeal metastasis (LM), brain metastasis (BM) and brain tumors (BT), which are associated with poor prognosis in patients.
Olga A. Sindeeva, Roman A. Verkhovskii, Mustafa Sarimollaoglu, Galina A. Afanaseva, Alexander S. Fedonnikov, Evgeny Yu. Osintsev, Elena N. Kurochkina, Dmitry A. Gorin, Sergey M. Deyev, Vladimir P. Zharov, Ekaterina I. Galanzha   +10 more
doaj   +1 more source

[Different Gene Mutation Spectrum of the Paired CSF and Plasma Samples in Lung Adenocarcinoma with Leptomeningeal Metastases: the Liquid Biopsy Based on Circulating Tumor DNA].

Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2020
Leptomeningeal metastasis (LM) are a severe complication of non-small cell lung cancer (NSCLC), and normally accompanied by poor prognosis. For the patients with targetable mutations, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are the preferred treatment, but the acquired TKI resistance is inextricable.
Huiying LI, Yu XIE, Yongjuan LIN, Tingting YU, Zhenyu YIN   +4 more
openaire   +2 more sources

Liquid Biopsy for Detection of T790M Mutation in Patient with EGFR-Mutant Non-Small Cell Lung Cancer with Leptomeningeal Metastases: A Case Report [PDF]

, 2022
Introduction: Liquid biopsy is increasingly used in management of Non-Small Cell Lung Cancer(NSCLC), especially when tissue availability tumor is limited. This especially true in the context ofLeptomeningeal metastases. The circulating cell-free DNA from
Derasse, M., Grigoriu, Bogdan Dragos, Berghmans, Thierry, D'Haene, Nicky   +3 more
core  

ID #729 LBSeq4Kids clinical liquid biopsy platform demonstrates a high detection rate in CSF at diagnosis and facilitates sequential CSF monitoring for high-risk pediatric brain tumors

Neuro-Oncology Pediatrics
Abstract The LBSeqKids clinically validated liquid biopsy platform combines low passage whole genome sequencing (LP-WGS) to detect copy number alterations (CNAs) and a 136 gene targeted sequencing panel (TSP) to detect mutations in cerebrospinal fluid (CSF), aqueous humor of the eye and plasma in patients with solid tumors.
Tom Rosenberg, Laura Kagami, Katrina O’ Halloran, Erin White, Jacquelyn Jones, Susan Chi, Jaclyn Biegel   +6 more
openaire   +1 more source

Molecular analysis in liquid biopsies for diagnostics of primary central nervous system lymphoma: Review of literature and future opportunities [PDF]

, 2018
Primary central nervous system lymphoma (PCNSL) is an aggressive lymphoma with a poor prognosis, for which accurate and timely diagnosis is of utmost importance.
Monique C. Minnema, Huibers, Manon M H, Snijders, Tom J, Tom J. Snijders, Kuiper, Jonas J W, Minnema, Monique C, de Weger, Roel A, Roos J. Leguit, Jiwa, N Mehdi, Leguit, Roos J, Hiemcke-Jiwa, Laura S, N. Mehdi Jiwa, Roel A. de Weger, Manon M.H. Huibers, Laura S. Hiemcke-Jiwa, Jonas. J.W. Kuiper   +15 more
core   +1 more source

Ultrasound mediated blood-brain barrier opening increases brain tumor biomarkers: A review of preclinical and clinical trials

The Journal of Liquid Biopsy
The diagnosis of brain tumors typically relies on magnetic resonance imaging (MRI), computed tomography (CT), and invasive procedures like biopsies or surgical resection for confirmation and genetic profiling.
Muhammad Izhar, Abhimanyu Thakur, David J. Park, Steven D. Chang   +3 more
doaj   +1 more source

BIOM-02. DISSECTING CDK4/6 INHIBITOR RESISTANCE MECHANISMS IN RECURRENT PEDIATRIC BRAIN TUMORS WITH LONGITUDINAL CSF LIQUID BIOPSIES FROM THE SJDAWN CLINICAL TRIAL

Neuro-Oncology
Abstract BACKGROUND SJDAWN (NCT03434262) is a St. Jude Children’s Research Hospital phase 1 trial that assessed the safety and benefit of CDK4/6 inhibitor-based therapy in patients with relapsed CNS tumors. To capture tumor evolution dynamics and arising resistance mechanisms in response to treatment,
Han, Katie, Kostecka, Anna, Smith, Kyle S, Dhanda, Sandeep, Lin, Hong, Mikkelsen, Margit, Robinson, Giles W, Northcott, Paul A   +7 more
openaire   +1 more source

Diagnosis of pediatric central nervous system tumors using methylation profiling of cfDNA from cerebrospinal fluid

Clinical Epigenetics
Pediatric central nervous system tumors remain challenging to diagnose. Imaging approaches do not provide sufficient detail to discriminate between different tumor types, while the histopathological examination of tumor tissue shows high inter-observer ...
Lotte Cornelli, Ruben Van Paemel, Maísa R. Ferro dos Santos, Sofie Roelandt, Leen Willems, Jelle Vandersteene, Edward Baert, Liselot M. Mus, Nadine Van Roy, Bram De Wilde, Katleen De Preter   +10 more
doaj   +1 more source