Results 91 to 100 of about 10,378 (206)

Efficacy of different platforms in detecting EGFR mutations using cerebrospinal fluid cell‐free DNA from non‐small‐cell lung cancer patients with leptomeningeal metastases

Thoracic Cancer, 2023
Background Cell‐free tumor DNA (ctDNA) obtained through liquid biopsy is useful for the molecular analysis of advanced non‐small‐cell lung cancer (NSCLC).
Chi‐Lu Chiang, Hsiang‐Ling Ho, Yi‐Chen Yeh, Cheng‐Chia Lee, Hsu‐Ching Huang, Chia‐I Shen, Yung‐Hung Luo, Yuh‐Min Chen, Chao‐Hua Chiu, Teh‐Ying Chou   +9 more
doaj   +1 more source

Blood, CSF, and Urine Biomarkers for Paediatric Brain Tumours: A Systematic Review of Liquid Biopsy Approaches

Neuro-Oncology Pediatrics
Abstract Background Identification of non-invasive biomarkers in blood, cerebrospinal fluid (CSF), or urine could aid diagnosis and monitoring in paediatric brain tumours. Methods We searched MEDLINE, Embase, SCIE ...
Jack Read, Jinyue Yu, Craig Paterson, Farhad Shokraneh, Phillipa Davies, Julian P T Higgins, Kathreena M Kurian   +6 more
openaire   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Liquid biopsy for CNS lymphoma: CSF exosomes and CSF exosomal miR-15a, miR-21, miR-155, miR-210, and miR-19b are promising biomarkers for diagnosis

Molecular Biology Reports
Central nervous system lymphoma (CNSL) is a devastating disease with a poor prognosis. Early diagnosis, monitoring of the treatment response, and outcome prediction carry the utmost importance in the management of patients with CNSL. Surgical biopsy is the gold standard for tissue diagnosis, however, this procedure has potential complications ...
HATİBOĞLU M. A., KARAÇAM B., KHAN I., Akdur K., ELBASAN E. B., Mahfooz S., SEYİTHANOĞLU M. H., ÇETİN G., GUNDAG M., ÖZTANIR M. N.   +9 more
openaire   +3 more sources

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

BIOM-68. TAPS LIQUID BIOPSY: AN ULTRASENSITIVE, INTEGRATED GENOMIC-EPIGENETIC CSF ASSAY FOR CNS TUMORS

Neuro-Oncology
Abstract Liquid biopsy of cerebrospinal fluid (CSF)-derived circulating tumor DNA (ctDNA) has been shown to be a feasible and low-risk alternative to tissue sampling for patients with central nervous system (CNS) tumors. The implementation of CSF ctDNA liquid biopsy has proven challenging due to the molecular diversity of CNS diseases.
Fang, Camila S, Freitag, Eloise, Oviedo, Alexa, Schroff, Chanel, Hadi, Kevin, Deshpande, Aditya, Rafailov, Johnathan, Weiss, Hannah, Dhasmana, Neha, Zacharoulis, Stergios, Orringer, Daniel, Yang, Yiying, Wrzeszczynski, Kazimierz O, Imielinski, Marcin, Snuderl, Matija, Miller, Alexandra M   +15 more
openaire   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Demonstrating the clinical utility of genomic profiling using cerebrospinal fluid to inform management of central nervous system tumors – a meta analysis of the literature

The Journal of Liquid Biopsy
Purpose: Meta-analysis of literature was performed to gain an understanding of the performance of genomic profiling assays in cerebrospinal fluid (CSF) for the diagnosis and management of CNS cancers.
Sakshi Khurana, Qian Nie, Kala F. Schilter, Honey V. Reddi   +3 more
doaj   +1 more source

Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients

EMBO Molecular Medicine, 2018
Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell‐free tumor DNA (cftDNA) in cerebrospinal fluid (CSF) has been proposed as an alternative to detection in plasma.
Florent Mouliere, Richard Mair, Dineika Chandrananda, Francesco Marass, Christopher G Smith, Jing Su, James Morris, Colin Watts, Kevin M Brindle, Nitzan Rosenfeld   +9 more
doaj   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source