Results 101 to 110 of about 10,378 (206)
Capturing Genomic Evolution of Lung Cancers through Liquid Biopsy for Circulating Tumor DNA [PDF]
, 2017 Genetic sequencing of malignancies has become increasingly important to uncover therapeutic targets and capture the tumor’s dynamic changes to drug sensitivity and resistance through genomic evolution.
Bob T. Li +6 more
core +1 more source
Advancing Personalized Medicine in Alzheimer's Disease : Liquid Biopsy Epigenomics Unveil APOE ε4-Linked Methylation Signatures [PDF]
Recent studies show that patients with Alzheimer's disease (AD) harbor specific methylation marks in the brain that, if accessible, could be used as epigenetic biomarkers.
Corroza, J. +18 more
core +3 more sources
Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile
Annals of Neurology, Volume 100, Issue 2, Page 255-267, August 2026.Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale +17 more
wiley +1 more source
Journal of the Neurological SciencesAutoimmune encephalitis (AE) has become the primary framework for evaluating subacute neurological decline in emergency and hospitalized patients. The field's success in identifying antibody-mediated syndromes has been remarkable but that success has created a blind spot.
openaire +1 more source
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aims Neuroblastoma is the most common extracranial solid tumor and contributes the most to pediatric oncology deaths worldwide. Its clinical manifestations are heterogeneous, including relapses, and the prognosis remains poor, especially for high‐risk patients.
Mosammat Jannatul Mawa +3 more
wiley +1 more source
The Journal of Liquid BiopsyLiquid biopsy can expose spatially segregated resistance biology that is invisible to single-site tissue testing, particularly across the blood–brain barrier.
Kei Kunimasa +8 more
doaj +1 more source
Turning Cold Tumors Into Hot Tumors: Implications for Cancer Therapy
MedComm, Volume 7, Issue 8, August 2026.Barrier‐defined strategies for cold‐to‐hot tumor conversion. Cold tumors include immune‐desert and immune‐excluded states marked by poor antigen visibility, limited T‐cell priming, stromal or vascular exclusion, metabolic stress and suppressive immune programs.
Xiao Ge +5 more
wiley +1 more source
MedComm, Volume 7, Issue 8, August 2026.This study introduces NeoAPP, a computational tool revealing that transcriptional dysregulation generates a dominant reservoir of neoantigens from tumor‐specific transcripts (TSTs) in pancreatic ductal adenocarcinoma (PDAC), far exceeding those of mutational origin.
Jingjing Zhao +14 more
wiley +1 more source
Emerging Immune‐Based Therapeutic Strategies in Hepatocellular Carcinoma
Liver International, Volume 46, Issue 8, August 2026.ABSTRACT Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide despite recent advances in systemic therapy. The introduction of immune checkpoint inhibitors has substantially expanded treatment options for advanced disease; however, durable responses are observed only in a subset of patients.
Janine Kah +2 more
wiley +1 more source
Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.ABSTRACT Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a fatal neurodegenerative disease primarily affecting motor neurons. Two key protein inclusions found in lower motor neurons serve as neuropathological hallmarks of the disease in human tissue: the TDP43‐positive inclusion and the cystatin C‐positive Bunina body.
Sarah M. Granger +5 more
wiley +1 more source