Results 181 to 190 of about 10,378 (206)

JS08.6.A CSF DERIVED LIQUID BIOPSIES FOR GLIOMA DIAGNOSIS

Neuro-Oncology, 2023
Abstract BACKGROUND Distinctive genetic changes can identify various types of gliomas. However, acquiring tumor material via surgery in the central nervous system (CNS) can pose the danger of neurological impairments, especially if the tumor is located near critical areas or in the brain stem. Gliomas
F Iser, C Güngör, J Meyer, L Dörner, L Hofmann, N Graßl, A Patel, B Wildemann, M Platten, W Wick, F Sahm, T Kessler   +11 more
openaire   +1 more source

Liquid Biopsy and Other Non-Invasive Diagnostic Measures in PCNSL [PDF]

Cancers, 2021
Primary central nervous system lymphoma is a rare but highly aggressive form of non-Hodgkin lymphoma that remains confined to the CNS neuroaxis. The diagnosis of PCNSL requires a high level of suspicion as clinical presentation varies depending on the ...
Alexander Baraniskin, Roland Schroers, Baraniskin Alexander   +2 more
exaly   +4 more sources

A review on genetic alterations in CNS metastases related to breast cancer treatment. Is there a role for liquid biopsies in CSF?

Journal of Neuro-Oncology, 2023
Acquired mutations or altered gene expression patterns in brain metastases (BM) and/or leptomeningeal metastases (LM) of breast cancer may play a role in therapy-resistance and offer new molecular targets and treatment options. Despite expanding knowledge of genetic alterations in breast cancer and their metastases, clinical applications for patients ...
Peter H, Wessels, Mirjam C, Boelens, Kim, Monkhorst, Gabe S, Sonke, Daan, van den Broek, Dieta, Brandsma   +5 more
openaire   +2 more sources

Liquid Biopsy for Glioma Using Cell-Free DNA in Cerebrospinal Fluid [PDF]

Cancers
Glioma is one of the most common primary central nervous system (CNS) tumors, and its molecular diagnosis is crucial. However, surgical resection or biopsy is risky when the tumor is located deep in the brain or brainstem.
Ryusuke Hatae, Ryosuke Otsuji, Masahiro Mizoguchi   +2 more
exaly   +2 more sources

P14.10.AMYD88L265P MUTATION IN THE DIAGNOSIS OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA (PCNSL): CORRELATION BETWEEN TUMOUR TISSUE AND CEREBROSPINAL FLUID (CSF) BY LIQUID BIOPSY

Neuro-Oncology, 2023
Abstract BACKGROUND Primary Central Nervous System Lymphomas (PCNSLs) harbour MYD88L265P activating mutations in up to 70% of patients. Whether detection of MYD88L265P by liquid biopsy may be an accurate, non-invasive procedure for diagnosis and disease monitoring of PCNSL patients is a matter of ...
F Bruno, L Bertero, S Ferrero, F Cavallo, M Clerico, D Drandi, M Ferrante, L Mangherini, A A Ricci, C Manini, E Pronello, R Palmiero, A Pellerino, D Garbossa, R Soffietti, B Bruno, R Rudà   +16 more
openaire   +1 more source

Abstract B071: Identifying the clinical utility of CSF as a source of liquid biopsy in pediatric brain tumors

Clinical Cancer Research
Abstract Pediatric tumors of the central nervous system (CNS) are a leading cause of cancer-related childhood mortality. Along with imaging, it is essential to molecularly characterize tumor tissue for the diagnosis, treatment, and prognosis of these cancers.
Liana Nobre, Mansuba Rana, Yoshiko Nakano, Ian Burns, Robert Siddaway, Richard Yuditskiy, Cyril Li, Andrew Bondoc, Anthony Liu, Uri Taboori, Cynthia Hawkins   +10 more
openaire   +1 more source

GR.5 Establishing the utility of multi-platform liquid biopsy by integrating the CSF methylome and proteome in CNS malignancy

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Background: Liquid biopsy represents a major development in cancer research, with significant translational potential. Similarly, the integration of multiple molecular platforms has yielded novel insights into disease biology and heterogeneity. We hypothesise that applying contemporary multi-omic approaches to liquid biopsies will improve the power of ...
AP Landry, JA Zuccato, V Patil, M Voisin, JZ Wang, Y Ellenbogen, C Gui, A Ajisebutu, F Nassiri, G Zadeh   +9 more
openaire   +1 more source

506 Establishing the Utility of Multi-Platform Liquid Biopsy by Integrating the CSF Methylome and Proteome in CNS Tumours

Neurosurgery
INTRODUCTION: Liquid biopsy represents a major development in cancer research, with significant translational potential. Similarly, it is increasingly recognized that multi-omic molecular approaches are a powerful avenue through which to understand complex and heterogeneous disease biology. We hypothesize that merging these two
Alex Landry, Jeffrey Alexander Zuccato, Vikas Patil, Mathew Voisin, Justin Z. Wang, Yosef Ellenbogen, Chloe Gui, Andrew A. Ajisebutu, Thomas Kislinger, Farshad Nassiri, Gelareh Zadeh   +10 more
openaire   +1 more source

132 Optimizing Success Rates of CSF Liquid Biopsy Examined With Next Generation Sequencing in Pediatric Central Nervous System Tumors

Neurosurgery
INTRODUCTION: Cerebrospinal fluid (CSF) liquid biopsy presents an attractive option for minimally invasive diagnosis and follow up for pediatric brain tumors. Best practice for obtaining appropriate cfDNA for next generation sequencing (NGS) is not currently known.
Nicholas Chapman, Peter Chiarelli, Katrina O'Halloran, Jaclyn Biegel, Mark D. Krieger   +4 more
openaire   +1 more source

Abstract B015: CSF liquid biopsies reveal disease status and resistance mechanisms in children undergoing targeted therapy for malignant brain tumors

Clinical Cancer Research
Abstract BACKGROUND: Patients with relapsed or refractory brain tumors face poor outcomes due to the aggressive nature of their disease. Recent studies suggest that administration of cell cycle inhibitors may help slow tumor progression. In the Phase I trial SJDAWN (NCT03434262) conducted at St.
Katie Han, Kyle S Smith, Anna Kostecka, Sandeep Dhanda, Hong Lin, Margit Mikkelsen, Giles W Robinson, Paul A Northcott   +7 more
openaire   +1 more source