Results 201 to 210 of about 1,649,172 (225)

Integrated detection of cerebrospinal fluid cfDNA/cfRNA and molecular concordance with glioma characteristics. [PDF]

Neurooncol Adv
Sun M, Jiang S, Xu H, Zeng Y, Liu B, Wang Y, Li Z, Guan Y, Chen J, Zhu R, Ping W, Teng Y, Yan S, Liu L, Shen D, Tang Q, Fan Z, Ng HK, Qin Z, Mao Y, Shi Z.   +20 more
europepmc   +1 more source

Analytical Validation and Clinical Sensitivity of the Belay Summit™ 2.0 Cerebrospinal Fluid Liquid Biopsy Test-An Expanded Comprehensive Genomic Profiling Platform for Central Nervous System Malignancies. [PDF]

Cancers (Basel)
Khurana S, Keo V, Larson A, Udhane V, Adams JN, Acevedo A, Peltier T, Sanchez D, Domagala BA, Vo SA, Mitchell K, Ellis D, Muhammedov B, Al-Saffar SI, Hernandez KM, Bettegowda C, Douville C, Schilter KF, Nie Q, Reddi HV.   +19 more
europepmc   +1 more source

Advanced Imaging and Biomarker Discovery for Early Diagnosis in Skull Base Pathology. [PDF]

Asian J Neurosurg
Gupta K, Gupta S.
europepmc   +1 more source

CSF-based liquid biopsy pointing to a diagnosis of diffuse glioma in a patient with supposed neurodegenerative disorder

Neurological Sciences, 2023
The differential diagnosis of brain diseases becomes challenging in cases where imaging is not sufficiently informative, and surgical biopsy is impossible or unacceptable to the patient.An elderly patient with progressive short-term memory loss and cognitive impairment presented with a normal brain CT scan, a brain FDG-PET that indicated symmetrical ...
Massimo Filippi, Gaetano Finocchiaro
exaly   +5 more sources

A review on genetic alterations in CNS metastases related to breast cancer treatment. Is there a role for liquid biopsies in CSF?

Journal of Neuro-Oncology, 2023
Acquired mutations or altered gene expression patterns in brain metastases (BM) and/or leptomeningeal metastases (LM) of breast cancer may play a role in therapy-resistance and offer new molecular targets and treatment options. Despite expanding knowledge of genetic alterations in breast cancer and their metastases, clinical applications for patients ...
Peter H. Wessels, Mirjam C. Boelens, Kim Monkhorst, Gabe S. Sonke, Daan van den Broek, Dieta Brandsma   +5 more
openalex   +3 more sources

Abstract B071: Identifying the clinical utility of CSF as a source of liquid biopsy in pediatric brain tumors

Clinical Cancer Research
Abstract Pediatric tumors of the central nervous system (CNS) are a leading cause of cancer-related childhood mortality. Along with imaging, it is essential to molecularly characterize tumor tissue for the diagnosis, treatment, and prognosis of these cancers.
Liana Nobre, Mansuba Rana, Yoshiko Nakano, Ian Burns, Robert Siddaway, Richard Yuditskiy, Cyril Li, Andrew Bondoc, Anthony Liu, Uri Taboori, Cynthia Hawkins   +10 more
openalex   +2 more sources

506 Establishing the Utility of Multi-Platform Liquid Biopsy by Integrating the CSF Methylome and Proteome in CNS Tumours

Neurosurgery
INTRODUCTION: Liquid biopsy represents a major development in cancer research, with significant translational potential. Similarly, it is increasingly recognized that multi-omic molecular approaches are a powerful avenue through which to understand complex and heterogeneous disease biology. We hypothesize that merging these two
Alex Landry, Jeffrey Zuccato, Vikas Patil, Mathew Voisin, Justin Z. Wang, Yosef Ellenbogen, Chloe Gui, Andrew Ajisebutu, Thomas Kislinger, Farshad Nassiri, Gelareh Zadeh   +10 more
openalex   +2 more sources

132 Optimizing Success Rates of CSF Liquid Biopsy Examined With Next Generation Sequencing in Pediatric Central Nervous System Tumors

Neurosurgery
INTRODUCTION: Cerebrospinal fluid (CSF) liquid biopsy presents an attractive option for minimally invasive diagnosis and follow up for pediatric brain tumors. Best practice for obtaining appropriate cfDNA for next generation sequencing (NGS) is not currently known.
Nicholas Chapman, Peter A. Chiarelli, Katrina O’Halloran, Jaclyn A. Biegel, Mark D. Krieger   +4 more
openalex   +2 more sources

Abstract B015: CSF liquid biopsies reveal disease status and resistance mechanisms in children undergoing targeted therapy for malignant brain tumors

Clinical Cancer Research
Abstract BACKGROUND: Patients with relapsed or refractory brain tumors face poor outcomes due to the aggressive nature of their disease. Recent studies suggest that administration of cell cycle inhibitors may help slow tumor progression. In the Phase I trial SJDAWN (NCT03434262) conducted at St.
Katie Han, Kyle Smith, Anna Kostecka, Sandeep Kumar Dhanda, Hong Lin, Margit Mikkelsen, Giles Robinson, Paul A. Northcott   +7 more
openalex   +2 more sources