Results 11 to 20 of about 3,801 (175)

Dual NDP52 Function in Persistent CSFV Infection [PDF]

Frontiers in Microbiology, 2020
Viruses have evolved many mechanisms to escape host antiviral responses. Previously, we found that classical swine fever virus (CSFV) infection induces autophagy using the autophagosome as a self-replication site, thereby evading the host immune response
Shuangqi Fan, Keke Wu, Chaowei Luo, Xin Li, Mengpo Zhao, Dan Song, Shengming Ma, Erpeng Zhu, Yuming Chen, Hongxing Ding, Lin Yi, Jun Li, Mingqiu Zhao, Jinding Chen   +13 more
doaj   +3 more sources

Characterization of a Cytopathogenic Reporter CSFV [PDF]

Viruses, 2021
Cytopathogenic (cp) pestiviruses frequently emerge in cattle that are persistently infected with the bovine viral diarrhea virus (BVDV) as a consequence of RNA recombination and mutation. They induce apoptosis in infected tissue cultures, are highly attenuated in the immunocompetent host, and unable to establish persistent infections after diaplacental
Reuscher, Carina, Schmidt, Lisa, Netsch, Anette, Lamp, Benjamin Jakob Joachim, Justus Liebig University Giessen   +4 more
openaire   +5 more sources

Establishment and Evaluation of a Multicolor Latex Microsphere-Based Lateral Flow Immunoassay for the Simultaneous Detection of Antibodies Against African and Classical Swine Fever Viruses. [PDF]

Transbound Emerg Dis
African swine fever (ASF), a highly fatal disease often termed the “number one killer” of pigs, presents clinical symptoms indistinguishable from classical swine fever (CSF), such as fever, diarrhea, and vomiting, complicating on‐site differential diagnosis.
Chen J, Shi Z, Ru Y, Luo J, Yang Q, Xie Y, Wang L, Zhou J, Zhang X, Wei J, Zhu Y, Tian H, Zheng H, Chen NH.   +13 more
europepmc   +2 more sources

CSFV proliferation is associated with GBF1 and Rab2 [PDF]

Journal of Biosciences, 2016
The Golgi apparatus and its resident proteins are utilized and regulated by viruses to facilitate their proliferation. In this study, we investigated Classical swine fever virus (CSFV) proliferation when the function of the Golgi was disturbed. Golgi function was disturbed using chemical inhibitors, namely, brefeldin A (BFA) and golgicide A (GCA), and ...
Liang, Wulong, Zheng, Minping, Bao, Changlei, Zhang, Yanming   +3 more
openaire   +2 more sources

LDHB inhibition induces mitophagy and facilitates the progression of CSFV infection [PDF]

Autophagy, 2020
Cellular metabolism caters to the energy and metabolite needs of cells. Although the role of the terminal metabolic enzyme LDHB (lactate dehydrogenase B) in the glycolysis pathway has been widely studied in cancer cells, its role in viral infection is relatively unknown.
Shuangqi, Fan, Keke, Wu, Mingqiu, Zhao, Jin, Yuan, Shengming, Ma, Erpeng, Zhu, Yuming, Chen, Hongxing, Ding, Lin, Yi, Jinding, Chen   +9 more
openaire   +2 more sources

A Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Protect Pigs against a Virulent CSFV Challenge

Viruses, 2023
Classical swine fever (CSF) remains one of the most economically significant viral diseases affecting domestic pigs and wild boars worldwide. To develop a safe and effective vaccine against CSF, we have constructed a triple gene-deleted pseudorabies virus (PRVtmv)-vectored bivalent subunit vaccine against porcine circovirus type 2b (PCV2b) and CSFV ...
Ediane Silva, Elizabeth Medina-Ramirez, Selvaraj Pavulraj, Douglas P. Gladue, Manuel Borca, Shafiqul I. Chowdhury   +5 more
openaire   +3 more sources

MERTK is a host factor that promotes classical swine fever virus entry and antagonizes innate immune response in PK-15 cells

Emerging Microbes and Infections, 2020
Classical swine fever virus (CSFV) is a member of the genus Pestivirus in the Flaviviridae family. To date, the host factors required for CSFV entry remain poorly characterized.
Guanglai Zheng, Lian-Feng Li, Yuexiu Zhang, Liang Qu, Wenjing Wang, Miao Li, Shaoxiong Yu, Mo Zhou, Yuzi Luo, Yuan Sun, Muhammad Munir, Su Li, Hua-Ji Qiu   +12 more
doaj   +1 more source

Lactate facilitates classical swine fever virus replication by enhancing cholesterol biosynthesis

iScience, 2022
Summary: An emerging topic in virology is that viral replication is closely linked with the metabolic reprogramming of host cells. Understanding the effects of reprogramming host cell metabolism due to classical swine fever virus (CSFV) infection and the
Xiaodong Zou, Yang Yang, Feng Lin, Jiahuan Chen, Huanyu Zhang, Linquan Li, Hongsheng Ouyang, Daxin Pang, Linzhu Ren, Xiaochun Tang   +9 more
doaj   +1 more source

Adverse Effects of Classical Swine Fever Virus LOM Vaccine and Jeju LOM Strains in Pregnant Sows and Specific Pathogen-Free Pigs

Pathogens, 2019
In Jeju island of South Korea, a classical swine fever (CSF) non-vaccinated region, many pig farmers insisted on abortion and stillbirth in pregnant sows and high mortality of suckling/weaning piglets by circulating CSF virus from 2014 to 2018.
SeEun Choe, Jae-Hoon Kim, Ki-Sun Kim, Sok Song, Ra Mi Cha, Wan-Choul Kang, Hyeun-Ju Kim, Gyu-Nam Park, Jihye Shin, Hyoung-Nam Jo, In-Soo Cho, Bang-Hun Hyun, Bong-Kyun Park, Dong-Jun An   +13 more
doaj   +1 more source

Self-Assembling Nanovaccine Enhances Protective Efficacy Against CSFV in Pigs [PDF]

Frontiers in Immunology, 2021
Classical swine fever virus (CSFV) is a highly contagious pathogen, which pose continuous threat to the swine industry. Though most attenuated vaccines are effective, they fail to serologically distinguish between infected and vaccinated animals, hindering CSFV eradication.
Ze-Hui Liu, Hui-Ling Xu, Guang-Wei Han, Li-Na Tao, Ying Lu, Su-Ya Zheng, Wei-Huan Fang, Wei-Huan Fang, Fang He, Fang He   +9 more
openaire   +3 more sources