Results 261 to 270 of about 281,124 (345)

AMSC‐sEVs Ameliorated Crohn's Disease by Inhibiting Macrophage‐Myofibroblast Transition Through the Delivery of MFGE8

Cell Proliferation, EarlyView.
Our study demonstrated that TGF‐β1 activated MAPK signalling pathway and promoted the MMT and secretion of CCL17 under CD‐associated intestinal inflammatory conditions. AMSC‐sEVs can deliver MFGE8, which inhibits MMT and CCL17‐mediated Treg recruitment by suppressing the MAPK signalling pathway, thereby alleviating intestinal fibrosis.
Minghao Xie, Qiang Liu, Zhizhong Xiong, Jian Li, Ruiri Jin, Lei Lian, Zhengrong Li   +6 more
wiley   +1 more source

Liquid biopsy in malignant primary bone tumors: Clinical applications of circulating tumor DNA and circulating tumor cells for diagnosis, prognosis and treatment monitoring (Review). [PDF]

Oncol Rep
Tian B, Chen X, Zheng J, Kang X.
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Decoding Brain Metastasis With Liquid Biopsy: Biomarkers and Technologies in EGFR-Mutant NSCLC. [PDF]

Cancer Med
Sun Y, Wang Q, Zhu P, Li Z, Liu T, Yin R.   +5 more
europepmc   +1 more source

Socioeconomic status, environmental factors, and motor function in children with cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To investigate the association between socioeconomic status and cerebral palsy (CP) motor function, adjusting for known clinical and candidate environmental risk factors, that is, air pollution and distance to a children's treatment center (CTC).
Hana F Alazem, Ewa Sucha, Richard J Webster, Michelle L Larin, Anna M McCormick, Darcy L Fehlings, CP‐NET Group, Craig Campbell, Jan Willem Gorter, Carolyn Hunt, Anita Jethwa, Anne Kawamura, Marie Kim, Ronit Mesterman, Dawa Samdup   +14 more
wiley   +1 more source

Detection and Characterisation of Circulating Tumour Cell Clusters in Neuroblastoma. [PDF]

Cancers (Basel)
Bell Z, Merugu S, Jamieson D, Tweddle DA, Danilenko M.   +4 more
europepmc   +1 more source

Do aphid endosymbiotic bacteria influence parasitoid searching behaviour through changes in aphid honeydew production?

Ecological Entomology, EarlyView.
Hamiltonella defensa infection increases honeydew production in certain aphid genotypes, potentially modifying aphid feeding behaviour. Parasitoid wasps, Aphidius ervi, are more attracted to honeydew from H. defensa‐infected aphids; though larger honeydew amounts may slightly deter searching.
Desiré Macheda, Alexandre Foito, Katharine F. Preedy, Colin J. Alexander, Ankush Prashar, Alison J. Karley   +5 more
wiley   +1 more source

TASU2: Controllable CTC Simulation for Alignment and Low-Resource Adaptation of Speech LLMs

Jing Peng, Chenghao Wang, Yi Yang, Lirong Qian, Junjie Li, Yu Xi, Shuai Wang, Kai Yu   +7 more
openalex   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Circulating tumor cells in myeloma are a compound biomarker for bone marrow high-risk genomic alterations and tumor load.

Blood
Fokkema C, Bertamini L, de Jong MME, Tahri S, Hofste Op Bruinink D, Kellermayer Z, Papazian N, den Hollander C, Vermeulen MPW, Stoetman ECG, van Beek G, Hoogenboezem R, van der Velden VHJ, Hulin C, Perrot A, Moreau P, Rowe M, Vieyra D, Carson R, van Duin M, Sanders MA, Broijl A, Sonneveld P, Cupedo T.   +23 more
europepmc   +1 more source