Results 101 to 110 of about 11,409 (260)

Expression of insulin‐like growth factor‐1 receptor in circulating tumor cells of patients with breast cancer is associated with patient outcomes

Molecular Oncology, 2018
In patients with breast cancer, markers of aggressiveness such as dysregulation of the insulin‐like growth factor receptor (IGF1R) system and E‐cadherin loss are commonly observed.
Maria Spiliotaki, Dimitris Mavroudis, Maria Kokotsaki, Eleni‐Kyriaki Vetsika, Ioannis Stoupis, Alexios Matikas, Galatea Kallergi, Vassilis Georgoulias, Sofia Agelaki   +8 more
doaj   +1 more source

Identification of CTCs by imFISH.

, 2018
(A) DAPI,blue; (B) CEP8,orange; (C) CD45, red; (D) merge. It shows CTCs as triploid CEP8+/ DAPI+/CD45- and WBC as diploid CEP8+/DAPI+/CD45+ (D).
Xiao-Long Chen (399535), Yue-Feng Wen (3797491), Tian-Tian Cheng (5676839), Wen-Jin Huang (3797494), Hai-Hua Peng (3797500), Li-Si Zeng (3797506), Tong-Chong Zhou (3797503), Xiao-Dan Lin (3797497)   +7 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Exploring the platelet and cancer cell interaction in metastasis targeting

Journal of Current Oncology and Medical Sciences
Platelets are small anucleated cell fragments that ensure the stopping of bleeding. In blood metastasis of cancer, Platelets are essential. One of the most important aspects of cancer metastasis is the interaction between platelets and circulating tumor ...
Maria Riaz, Muhammad Zubair, Muhammad Kaleem Iqbal, Syed Muhammad Ahmad Bukhari, Hafiz Muhammad Sultan   +4 more
doaj  

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis

Signal Transduction and Targeted Therapy
Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination could lay the foundation for therapeutic ...
Chuan Yang, Xueping Wang, Kenneth K. W. To, Caimei Cui, Min Luo, Shaocong Wu, Lamei Huang, Kai Fu, Can Pan, Zeyu Liu, Teng Fan, Caibo Yang, Fang Wang, Liwu Fu   +13 more
doaj   +1 more source

Three-Dimensional Telomeric Analysis of Isolated Circulating Tumor Cells (CTCs) Defines CTC Subpopulations

, 2013
Circulating tumor cells (CTCs) have been identified with the potential to serve as suitable biomarkers for tumor stage and progression, but the availability of effective isolation technique(s) coupled with detailed molecular characterization have been ...
Xu, Mark Chu,, Awe, Julius Adebayo,, Mai, Sabine, Wechsler, Janine,, Mai, S., Cayre, Y. E., Drachenberg, Darrel, Drachenberg, D., Benali-Furet, Naoual, Adebayo Awe, Julius, Benali-Furet, N., Drachenberg, Darrel,, Saranchuk, Jeff, Saranchuk, Jeff,, Xu, M. C., Mai, Sabine,, Xu, Mark Chu, Wechsler, J., Wechsler, Janine, Cayre, Yvon E., Benali-Furet, Naoual,, Saranchuk, J., Cayre, Yvon E,   +22 more
core   +1 more source

Toward Sustainable Smart Packaging: Demonstration of Laser‐Induced Graphene Sensors on Orange‐Based Substrates

Advanced Electronic Materials, EarlyView.
Orange peel waste is directly transformed into biodegradable bioplastic films and converted into electronically active laser‐induced graphene (LIG) sensors through single‐step 450 nm laser scribing. Without requiring conductive inks, metallic coatings, or transfer steps, localized photothermal conversion creates porous 3D graphitic networks with sheet ...
Sonia Gómez‐Gijón, Siham Mebarek, Ekta Yadav, Yann Houeix, Pietro Ibba, Danila Merino, Almudena Rivadeneyra   +6 more
wiley   +1 more source

Dynamic Monitoring of CTCs and EVs to Predict Chemoimmunotherapy Efficacy in Lung Cancer

Biomedicines
Background: Circulating tumor cells (CTCs), programmed cell death-ligand 1 (PD-L1) positive CTCs (PD-L1+CTCs) and extracellular vesicles (EVs) are important biomarkers for predicting treatment efficacy. This study comprehensively investigated the factors
Chao Zhao, Lei Cheng, Jia Yu, Guanghui Gao, Menghang Yang, Fan Wu, Xuefei Li, Shengxiang Ren   +7 more
doaj   +1 more source

The prognostic value of JUNB-positive CTCs in metastatic breast cancer: from bioinformatics to phenotypic characterization

, 2019
Περίληψη: Background: Circulating tumor cells (CTCs) are important for metastatic dissemination of cancer. They can provide useful information, regarding biological features and tumor heterogeneity; however, their detection and characterization are ...
Sfakianakis Stelios G., Koutsopoulos A.V., Stournaras Christos, Ζερβακης Μιχαηλ(http://users.isc.tuc.gr/~mzervakis), Kallergi Galatea, Georgoulias Vassilis A., Μπεη Αικατερινη(http://users.isc.tuc.gr/~abei), Alkahtani Saad Hussin, Tsintari Vasileia, Bei Aikaterini(http://users.isc.tuc.gr/~abei), Zacharopoulou Nefeli, Lagoudaki Eleni D., Alarifi Saud A., Zervakis Michail(http://users.isc.tuc.gr/~mzervakis)   +13 more
core   +1 more source