Results 131 to 140 of about 112,774 (309)

Environmentally induced stress affects fitness of bold and shy alike: A long‐term study of personality and feather corticosterone in Arctic‐breeding kittiwakes

Journal of Animal Ecology, EarlyView.
Quantifying how individuals differ as their environment changes around them is crucial to predict population responses to climate change. By incorporating personality, physiology and life‐history the authors show that while environmental change is likely to impact the whole population equally, when individuals are most impacted will vary across the ...
Frederick C. Mckendrick, Samantha C. Patrick, Sébastien Descamps, Alexis P. Will, Kathryn E. Arnold, Stephanie M. Harris, Alexander S. Kitaysky   +6 more
wiley   +1 more source

Temporal Trends in Pregnancy Outcomes Among Parents With Type 1 Diabetes: A Nationwide Register‐Based Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To assess temporal trends in outcomes of pregnancies with maternal or paternal type 1 diabetes compared to the general population. Design Register‐based study. Setting Denmark. Population 1 551 893 pregnancies from 1997 to 2021, hereof 5478 with maternal and 8072 with paternal type 1 diabetes.
Tina Wullum Gundersen, Sine Knorr, Lene Ringholm, Dorte Moeller Jensen, Peter Damm, Karoline Kragelund Nielsen, Helena Backman, Jeannet Lauenborg, Elisabeth Reinhardt Mathiesen, Anne Helby Petersen, Niels Skipper, Allan Kofoed‐Enevoldsen, Tine Dalsgaard Clausen   +12 more
wiley   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, EarlyView.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Prevalence and Spectrum of Congenital Heart Disease in Individuals With Distal Chromosome 22q11.22–23 Deletions

Clinical Genetics, EarlyView.
The frequency and severity of congenital heart disease vary extensively in individuals with 22q11.22–23 distal deletions. Reduced gene dosage particularly within the low copy repeat (LCR22) D–E region including MAPK1 and HIC2 conveys risk for these defects.
Tanner J. Nelson, Daniel E. McGinn, T. Blaine Crowley, Lydia Rockart, Audrey Green, Victoria Giunta, Oanh Tran, Daniella Miller, Jeroen Breckpot, Ann Swillen, M. Cristina Digilio, Marta Unolt, Carolina Putotto, Federica Pulvirenti, Bruno Marino, Beverly S. Emanuel, Elaine H. Zackai, Zhengdong D. Zhang, Elizabeth Goldmuntz, Erik Boot, Anne S. Bassett, Bernice E. Morrow, Donna M. McDonald‐McGinn   +22 more
wiley   +1 more source

ITGA5 as a Dual Regulator of Epithelial‐Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction

Cell Proliferation, EarlyView.
Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang, Ling Rao, Xiaofang Li, Miaofen Zhang, Huiting Huang, Zhiyan Luo, Gang Liao, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang   +10 more
wiley   +1 more source

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

KU80 suppresses endonuclease G activity to preserve genomic integrity

The FEBS Journal, EarlyView.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan, Kwang‐Hyun Park, Hae Ryung Chang, Eunyoung Jung, Myung‐Jin Kim, Jeeyoon Kang, Hyunjo Shim, Eui‐Jeon Woo, Yonghwan Kim   +8 more
wiley   +1 more source

Decadal Rapid Change in Energetic Carrying Capacity for Juvenile Chum Salmon in the Sanriku Coast

Fisheries Oceanography, EarlyView.
ABSTRACT Adult returns to coastal rivers in Sanriku, located near the southernmost area of chum salmon distribution, have declined since 2010. Climate‐induced fluctuations in juvenile prey availability may affect growth and survival, which are linked to adult returns.
Yuki Iino, Yuichi Shimizu, Tomoki Sato, Takashi Kitagawa   +3 more
wiley   +1 more source

Environmental Drivers of Jumbo Squid During Fishery Collapse in the Gulf of California (2019–2024)

Fisheries Oceanography, EarlyView.
ABSTRACT The jumbo squid (Dosidicus gigas) is a cephalopod endemic to the eastern Pacific with significant ecological and economic importance. Its exploitation in the Gulf of California (GC) peaked in the 1990s, with catches exceeding 100,000 tons, but collapsed in 2009 and virtually disappeared by 2015, largely due to environmental changes and ...
Mario Vásquez‐Ortiz, Juan Roberto F. Vallarta‐Zárate, Jesús E. Osuna‐Soto, Emma Verónica Pérez‐Flores, Leslie Altamirano‐López, Ramón Isaac Rojas‐González   +5 more
wiley   +1 more source