Results 191 to 200 of about 112,774 (309)

Blood culture diagnostics - a comparative and experimental study on the impact of delayed incubation. [PDF]

BMC Microbiol
Jensen AJØ, Thomsen L, Sunnerhagen T, Lerche CJ, Moser C.   +4 more
europepmc   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

Cardiovascular Functioning Features in Individuals with Connective Tissue Dysplasia Engaged in Sports for the Disabled. [PDF]

Sports (Basel)
Vinokurova K, Zakharova A, Zinovieva Y, Epifanov A, Galdobina A, Sharkova E, Blyakhman F.   +6 more
europepmc   +1 more source

Process studies in the hydro- and geosphere of the tropical/subtropical North Atlantic Cruise No. 04 December 03, – April 03, 2006/2007, Fort de France (Martinique) – Las Palmas (Spain) [PDF]

, 2010
Borowski, C., Fischer, G., Flüh, Ernst R., Freudenthal, T., Müller, Thomas J.   +4 more
core  

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, Volume 13, Issue 13, 3 March 2026.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

A bacterial translation activator with an intrinsically disordered RNA-binding region. [PDF]

Proc Natl Acad Sci U S A
Basu P, Farland EA, Charity JC, Townsend KA, Dove SL.   +4 more
europepmc   +1 more source

WHP Cruise Summary Information of section A03 [PDF]

, 1993
Tereschenkov, Vladimir
core  

Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease

Arthritis &Rheumatology, Volume 78, Issue 3, Page 566-581, March 2026.
Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman, Voon Ong, Christopher P. Denton   +2 more
wiley   +1 more source

Conformations of Linker Histone H1 Bound to Nucleosome Arrays. [PDF]

J Mol Biol
Yuan B, Das SK, Wang W, Camacho G, Kumar A, Hayes JJ, Lee TH.   +6 more
europepmc   +1 more source

Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo, Cuilan Yun, Yuemei Zhang, Xu Yang, Huiqin Liu   +4 more
wiley   +1 more source