Results 231 to 240 of about 112,774 (309)

Hesperidin Attenuates H₂O₂‐Induced Neurotoxicity via Modulation of Inflammatory Pathways and MMP Activity in Differentiated SH‐SY5Y Cells: In Vitro and In Silico Models

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 3, March 2026.
Hesperidin protects differentiated SH‐SY5Y cells from H₂O₂‐induced neurotoxicity by reducing oxidative stress and suppressing pro‐inflammatory cytokines. It further inhibits NF‐κB/COX‐2 signaling and downregulates MMP‐2/MMP‐9 activity. In vitro findings are supported by in silico analyses showing strong binding to inflammatory targets. ABSTRACT Chronic
Hamiyet Eciroglu‐Sarban, Fatma Yildiz, Fatma Gonca Kocanci, Pinar Altin‐Celik, Muazzez Derya‐Andeden   +4 more
wiley   +1 more source

Connective Tissue Disease-Associated Pulmonary Arterial Hypertension: Current Therapeutic Strategies and Future Prospects. [PDF]

Biomolecules
Yokoyama YM, Watanabe R, Yamaguchi T, Ishihara R, Shiomi M, Fujita Y, Katsushima M, Fukumoto K, Haji Y, Yamada S, Hashimoto M.   +10 more
europepmc   +1 more source

Westerly winds prompted an anomalous southward migration of Pacific saury (Cololabis saira)

Limnology and Oceanography Letters, Volume 11, Issue 2, March 2026.
Abstract The Pacific saury (Cololabis saira), a key pelagic fish in the Northwest Pacific, exhibits autumn migration modulated by Kuroshio–Oyashio Extension mesoscale features, yet daily fishing ground variability remains unexplained. Traditional reliance on remote sensing data has limited understanding of the three‐dimensional mechanisms governing the
Yulei Zhang, Ruichen Zhu, Jianchao Li, Zhaohui Chen, Hao Tian, Yang Liu, Peng Sun, Zhenjiang Ye, Yongjun Tian   +8 more
wiley   +1 more source

Identification of receptor-binding domains of Bacteroidales antibacterial pore-forming toxins. [PDF]

J Biol Chem
Borgini S, Pasveer E, Petre C, Iorga BI, Vertommen D, Remaut H, Collet JF, Lauber F.   +7 more
europepmc   +1 more source

Relationships between acoustic scattering layers and ocean stratification: An acoustic approach to estimate mixed layer depth

Limnology and Oceanography: Methods, Volume 24, Issue 3, March 2026.
Abstract Ocean stratification, measured as mixed layer depth (MLD), is an important feature that influences many processes in the ocean; for example, by mediating the fluxes of momentum, heat and crucially key gases such as CO2 and oxygen from the atmosphere into the water column and vice versa. The conventional methods to measure stratification (e.g.,
Fabio Campanella, Jeroen van der Kooij, Liam Fernand   +2 more
wiley   +1 more source

Galectin-1 levels do not predict outcomes in undifferentiated arthritis: a two-year prospective observational study. [PDF]

Front Immunol
Valero-Martínez C, Pardines-Ortiz M, Montes N, Ortiz AM, García-Vicuña R, González-Alvaro I, Triguero-Martínez A.   +6 more
europepmc   +1 more source

Development of a moored radium in situ sampler to measure annual time series

Limnology and Oceanography: Methods, Volume 24, Issue 3, March 2026.
Abstract Radium is a useful tracer of sediment‐derived materials, improving our understanding of the geochemical cycling of elements at ocean boundaries. We have developed an autonomous in situ sampler to collect time series samples of radium isotopes on mooring deployments.
Lauren Kipp, Matthew A. Charette, Paul Henderson, Joshua Benedict, Igor Polyakov, Andrey Pnyushkov   +5 more
wiley   +1 more source

The Allosteric Regulation of the DNA-Binding Domain of p53 by the Intrinsically Disordered C-Terminal Domain. [PDF]

Pharmaceuticals (Basel)
Ning S, Zeng C, Wang H, Zhang J, Xue Y, Zhao Y.   +5 more
europepmc   +1 more source

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

Mass Spectrometry Reviews, Volume 45, Issue 2, Page 218-230, March/April 2026.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

Disruption of protein-protein interaction hotspots in the C-terminal domain of MLH1 confers mismatch repair deficiency. [PDF]

NAR Cancer
Fishwick KM, Gomez Vieito D, Greco G, Collotta G, Gatti M, Kulik AA, Guérois R, Corbeski I, Phadte AS, Senoussi I, Cejka P, Pluciennik A, Porro A, Sartori AA.   +13 more
europepmc   +1 more source