Results 101 to 110 of about 39,021 (326)

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source

Assessment of Circulating Tumor DNA for Early Detection of Hepatocellular Carcinoma in Alpha-Fetoprotein-Negative Patients With Cirrhotic Nodules. [PDF]

JGH Open
ABSTRACT Aims Early detection is essential for improving hepatocellular carcinoma's (HCC) prognosis. However, the diagnostic performance of the current interventions remains unsatisfactory, particularly in patients with cirrhotic nodules. We aimed to develop a predictive model for the early detection of HCC using circulating tumor DNA (ctDNA) profiles ...
Chang LJ, Yu MC, Lee WC, Chan FC, Pan YJ, Tai DI, Su WH.   +6 more
europepmc   +2 more sources

Dynamic Immune Cell Composition, Phenotypes, and Signaling in an Engineered Metastatic Niche

Biotechnology and Bioengineering, EarlyView.
ABSTRACT In breast cancer patients, metastasis is the stage of disease where prognosis significantly worsens. However, the timing at which metastasis initiates and the location of metastatic lesions in an organ are stochastic, limiting the timely identification of disease and the administration of treatments.
Rebecca S. Pereles, Jyotirmoy Roy, Michael D. Brooks, Max S. Wicha, Jacqueline S. Jeruss, Lonnie D. Shea, Sophia M. Orbach   +6 more
wiley   +1 more source

Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine [PDF]

, 2018
Approximately one-half of advanced (unresectable or metastatic) melanomas harbor a mutation in the BRAF gene, with V600E being the most common mutation.
Cheng, Liang, Lopez-Beltran, Antonio, MacLennan, Gregory T., Massari, Francesco, Montironi, Rodolfo   +4 more
core   +1 more source

Mechanisms of Resistance to Cancer Immunotherapy: A Host–Tumor Interaction Perspective; A Review Article

Cancer Nexus, EarlyView.
Mechanisms of resistance to cancer immunotherapy from a host–tumor interaction perspective. The central tumor cell is protected by multiple resistance mechanisms, including genetic mutations, epigenetic modifications, and metabolic alterations. The immunosuppressive tumor microenvironment features myeloid‐derived suppressor cells (MDSCs), regulatory T ...
Mohammed Elmujtba Adam Essa, Hamid Noori, Abdelkareem A. Ahmed   +2 more
wiley   +1 more source

Molecular Profiling of Hepatocellular Carcinoma Using Circulating Cell-Free DNA. [PDF]

, 2019
PurposeMolecular profiling has been used to select patients for targeted therapy and determine prognosis. Noninvasive strategies are critical to hepatocellular carcinoma (HCC) given the challenge of obtaining liver tissue biopsies.Experimental designWe ...
Abdel-Wahab, Reham, Amin, Hesham M, Banks, Kimberly C, Bocobo, Andrea G, George, Bhawana, Haque, Abedul, Hassan, Manal M, Ikeda, Sadakatsu, Kaseb, Ahmed O, Kelley, Robin K, Kurzrock, Razelle, Lanman, Richard B, Lim, Kian H, Meric-Bernstam, Funda, Mills-Shaw, Kenna R, Morris, Jeffrey, Pestana, Roberto Carmagnani, Qiao, Wei, Raghav, Kanwal PS, Rashid, Asif, Sen, Shiraj, Sánchez, Nora S, Talasaz, AmirAli, Tan, Benjamin, Uemura, Marc, Wolff, Robert A, Xiao, Lianchun, Yao, James C   +27 more
core   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

Anticancer potential of Tinospora cordifolia and arabinogalactan against benzo(a)pyrene induced pulmonary tumorigenesis: a study in relevance to various biomarkers [PDF]

, 2018
Introduction: Aqueous Tinospora cordifolia stem extract (Aq.Tc) and arabinogalactan (AG), its bioactive polysaccharide, which are antioxidant remedies were evaluated on pulmonary cancer and associated tumor markers.
Koul, Ashwani, Mohan, Vandana
core   +2 more sources

The Prognostic Impact of Early ctDNA Kinetics in Metastatic Pancreatic Cancer Using the ctDNA-RECIST [PDF]

Clinical Cancer Research
Abstract Purpose: Changes in ctDNA levels during systemic treatment may predict treatment efficacy in patients with metastatic pancreatic ductal adenocarcinoma (PDAC), but quantitative response criteria are not yet established. This study evaluates our recently proposed ctDNA-RECIST.
Mette M. Steiniche, Sidsel C. Lindgaard, Inna M. Chen, Julia S. Johansen, Rikke F. Andersen, Torben F. Hansen, Lars H. Jensen, Louise S. Rasmussen, Malene W. Johansen, Morten Ladekarl, Anders K.M. Jakobsen, Karen-Lise G. Spindler   +11 more
openaire   +3 more sources

Biopsy for Suspicious Oral Lesions: A Review From the American Head and Neck Society‐Cancer Prevention Service

Head &Neck, EarlyView.
ABSTRACT Background Oral cancer is often preceded by a precursor lesion. This presents an opportunity for early diagnosis and intervention. Method of biopsy and interpretation are not well standardized and novel methods of analysis are now being investigated.
James Christopher Gates, Heather Edwards, Alessandro Villa, Nick Purdy, Michael Troka, Peter Varela, Quinn Self, Yingci Liu, Yusuf Dundar, Patricia Joyce Brooks, Dauren Adilbay, Andrew Birkeland, John Cramer   +12 more
wiley   +1 more source