Results 101 to 110 of about 47,434 (363)

Interstrand DNA covalent binding of two dinuclear Ru(ii) complexes. Influence of the extra ring of the bridging ligand on the DNA interaction and cytotoxic activity [PDF]

, 2017
In this work, we report experimental and computational evidences for the intercalation into the DNA base pairs of the free quinones Quinizarin (Q), Naphthazain (N) and the interstrad covalent binding of their p-cymene di-Ruthenium(II) complexes (Cl2Ru2X,
Busto, Natalia, Carbayo, Arancha, Espino, Gustavo, García, Begoña, Leal, José M., Lozano, Héctor J., Platts, James   +6 more
core   +2 more sources

Targets, pitfalls and reference materials for liquid biopsy tests in cancer diagnostics [PDF]

, 2020
Assessment of cell free DNA (cfDNA) and RNA (cfRNA), circulating tumor cells (CTC) and extracellular vesicles (EV) in blood or other bodily fluids can enable early cancer detection, tumor dynamics assessment, minimal residual disease detection and ...
Geeurickx, Edward, Hendrix, An
core   +2 more sources

ctDNA for the Evaluation and Management of EGFR-Mutant Non-Small Cell Lung Cancer

Cancers
Simple Summary Lung cancer patients with a specific gene mutation often undergo tissue biopsies to guide treatment. But what if a simple blood test could do the same?
Aakash Desai, Tadana A. Vázquez, Keishla M. Arce, Marcelo Corassa, Philip C Mack, J.E. Gray, B. Pellini   +6 more
semanticscholar   +1 more source

The utility of ctDNA in detecting minimal residual disease following curative surgery in colorectal cancer: a systematic review and meta-analysis

British Journal of Cancer, 2022
Introduction Colorectal cancer is the fourth most common cancer in the UK. There remains a need for improved risk stratification following curative resection.
Lucy G Faulkner, L. Howells, C. Pepper, J. Shaw, Abin Varghese Thomas   +4 more
semanticscholar   +1 more source

MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9

Advanced Materials, EarlyView.
An advanced‐fidelity CRISPR nuclease, FnCas9‐AF2, is rationally engineered to discriminate single‐base mismatches with unprecedented level precision. Integrated into the MUTE‐Seq workflow, FnCas9‐AF2 depletes wild‐type cell‐free DNA, thereby exposing rare tumor‐derived mutant DNA (a molecular “needle in a haystack”).
Sunghyeok Ye, Jin‐Soo Kim, Myungshin Kim, Ki‐Yeon Kim, Yoon‐Ho Won, Taegun Park, Sungjae An, Haerin Jeong, Hee‐Joon Chung, In Seon Lee, Myoung‐Hee Kang, Chan Young Kang, Mi Young Kim, Jae Ho Chung, Jeong‐An Gim, Woochang Hwang, Yonggoo Kim, Song Cheol Kim, Sungho Lee, Junho K Hur, Junseok W Hur   +20 more
wiley   +1 more source

Circulating Tumor DNA in Primary and Secondary Liver Cancers: A Comprehensive Review

Frontiers in Bioscience-Scholar
Similar to many other cancer types, liver malignancies pose the common challenges of late detection of primary tumors and recurrences. Liquid biopsies, which assess the presence of circulating tumor DNA, have emerged as a novel, non-invasive clinical ...
Hanna Hong, Chase J Wehrle, Omer Faruk Karakaya, Noah Tocci, Pranav Kumar, Keyue Sun, Chunbao Jiao, Sangeeta Satish, Rebecca Panconesi, Jamak Modaresi Esfeh, Maureen Whitsett Linganna, Koji Hashimoto, Andrea Schlegel, Charles Miller, David C.H. Kwon, Federico Aucejo   +15 more
doaj   +1 more source

A headlight on liquid biopsies: a challenging tool for breast cancer management [PDF]

, 2016
Breast cancer is the most frequent carcinoma and second most common cause of cancer-related mortality in postmenopausal women. The acquisition of somatic mutations represents the main mechanism through which cancer cells overcome physiological cellular ...
Barraco, Nadia, BAZAN, Viviana, BRONTE, Giuseppe, CALO', Valentina, Cangemi, Antonina, CASTIGLIA, Marta, CICERO, Giuseppe, DI PIAZZA, Florinda, FANALE, Daniele, Massihnia, Daniela, PANTUSO, Gianni, Perez, Alessandro, RIZZO, Sergio, RUSSO, Antonio   +13 more
core   +1 more source

State of the Art: ctDNA in Upper Gastrointestinal Malignancies

Cancers, 2023
Circulating tumor DNA (ctDNA) has emerged as a promising non-invasive source to characterize genetic alterations related to the tumor. Upper gastrointestinal cancers, including gastroesophageal adenocarcinoma (GEC), biliary tract cancer (BTC) and pancreatic ductal adenocarcinoma (PADC) are poor prognostic malignancies, usually diagnosed at advanced ...
Ibone Labiano, Ana Elsa Huerta, Virginia Arrazubi, Irene Hernandez-Garcia, Elena Mata, David Gomez, Hugo Arasanz, Ruth Vera, Maria Alsina   +8 more
openaire   +2 more sources

Current and Future Clinical Applications of ctDNA in Immuno-Oncology

Cancer Research, 2021
Testing peripheral blood for circulating tumor DNA (ctDNA) offers a minimally invasive opportunity to diagnose, characterize, and monitor the disease in individual cancer patients.
J. Stadler, Yassine Belloum, B. Deitert, Mark Sementsov, Isabel Heidrich, C. Gebhardt, Laura Keller, K. Pantel   +7 more
semanticscholar   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source