Results 131 to 140 of about 47,434 (363)

The rationale for liquid biopsy in colorectal cancer: focus on circulating tumor cells [PDF]

, 2015
Capturing circulating tumor cells (CTCs) and/or circulating tumor DNA from blood, which represents a precious source of biological material derived from both primary and metastatic tumors, has been named a 'liquid biopsy'. While the circulating tumor DNA
Carletti, Raffaella, Cortesi, Enrico, DI GIOIA, Cira Rosaria Tiziana, Gazzaniga, Paola, Gradilone, Angela, Nicolazzo, Chiara, Raimondi, Cristina   +6 more
core   +1 more source

Conversion Therapy for cT4b and M1 Esophageal Squamous Cell Carcinoma: A Comprehensive Systematic Review

Annals of Gastroenterological Surgery, EarlyView.
We systematically reviewed conversion therapy for esophageal squamous cell carcinoma and propose a response‐based treatment strategy for cT4b and M1 disease. For cT4b, we emphasize definitive chemoradiotherapy with timed re‐evaluation and selective salvage or chemoselection to surgery; for M1, conversion is reserved for limited‐burden responders with ...
Eisuke Booka, Hiroya Takeuchi
wiley   +1 more source

The association of blood ctDNA levels to mutations of marker genes in colorectal cancer

Cancer Reports, 2023
Background Colorectal cancer (CRC) is a deadly and commonly diagnosed cancer. Cell‐free circulating tumor DNAs (ctDNA) have been used in the diagnosis and treatment of CRC, but there are open questions about the relationship between ctDNAs and CRC ...
Fei Bai, Qian Du, Qingliang Zou, Lin Xu, Wei Dong, Xinlin Lv, Xiaorong Han, Huijun Zhou, Chi Zhang, Tao Lu   +9 more
doaj   +1 more source

The potential for liquid biopsies in the precision medical treatment of breast cancer. [PDF]

, 2016
Currently the clinical management of breast cancer relies on relatively few prognostic/predictive clinical markers (estrogen receptor, progesterone receptor, HER2), based on primary tumor biology.
Barrak, Dany K, Elhodaky, Mostafa, Forte, Victoria A, Lang, Julie E, Snow, Anson, Tung, Lily   +5 more
core   +1 more source

AKT1 (E17K) mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection. [PDF]

, 2016
BACKGROUND: The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed in breast cancer. However, its precise role in disease etiology remains unknown. METHODS: We analyzed more than 600 breast
Anzeneder, Tobias, Beckmann, Georg, Byrne, Annette T, Jeffers, Michael, Köchert, Karl, Pena, Carol, Politz, Oliver, Reischl, Joachim, Rudolph, Marion, Schulz, Anke, Vonk, Richardus   +10 more
core   +1 more source

Approaches to Enhance Photodynamic Therapy of Lung Cancer: Potential Application of Nanoparticles

Advanced NanoBiomed Research, EarlyView.
Bioactive ligand‐targeted nanocarriers can accommodate functionalization with numerous targeting ligands for effective delivery of photosensitizers (PSs) within targeted photodynamic therapy. Various targeting moieties including peptides, antibodies, carbohydrates, aptamers, proteins, and PS anticancer molecules can be attached to nanomaterials.
Nokuphila Winifred Nompumelelo Simelane, Heidi Abrahamse   +1 more
wiley   +1 more source

High‐throughput exosomes analysis for ovarian cancer screening based on a double‐positive surface marker detection biochip

BMEMat, EarlyView.
A double‐positive surface marker detection approach was developed to conduct exosome surface protein detection in serum samples. It reaches single‐exosome detection, and over 300 exosome protein parameters are analyzed. The diagnostic accuracy achieved 90% in differentiation of high‐grade serous/serous ovarian carcinoma patients, benign patients, and ...
Jiaoyan Qiu, Yu Wu, Yihe Wang, Chao Wang, Soo‐Yeon Cho, Hui Huang, Yu Zhang, Lin Han   +7 more
wiley   +1 more source

Circulating tumor DNA in patients with cancer: insights from clinical laboratory

Advances in Laboratory Medicine
Blood-based circulating tumor DNA (ctDNA) analysis has emerged as a highly relevant non-invasive method for molecular profiling of solid tumors, offering valuable information about the genetic landscape of cancer.
Illana Francisco J., Fernández-Galán Esther, Muñoz-Bravo José Luis, Valiña Amado Laura, García Martín Carme, González-Fernández Carolina, Miró-Cañís Sílvia, Trapé Jaume, Martínez-Peinado Antonio, Filella Xavier, González Alvaro, Sánchez Antonio Barco, Díaz-Lagares Angel,   +13 more
doaj   +1 more source

EGFR inhibition in NSCLC: New findings\u2026. and opened questions? [PDF]

, 2017
The targeted inhibition of epidermal growth factor receptor (EGFR) has represented a milestone in the treatment of lung cancer. Several studies convincingly and consistently demonstrated a significant superiority of EGFR-TKIs over standard platinum ...
Bazan, V., Castiglia, M., Listi', A., Passiglia, F., Perez, A., Rizzo, S., Russo, A.   +6 more
core   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source