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Abstract LB106: Ultra-short ctDNA: A new paradigm for ctDNA liquid biopsy
Cancer ResearchAbstract Mononucleosomal ctDNA (mnctDNA, 157-bp, double-stranded) spearheads liquid biopsy (LB) for cancer detection, treatment and clinical care. The bottleneck of mnctDNA LB are low copy number of ctDNA and limit of detection of platform technologies.
Feng Li +8 more
openaire +1 more source
ctDNA-guided adjuvant immunotherapy in colorectal cancer
ImmunotherapyCirculating tumor DNA (ctDNA) represents a powerful measure of minimal residual disease (MRD) in colorectal cancer (CRC). Although immunotherapy has been widely established in metastatic CRC that is mismatch repair deficient or microsatellite instability-high (dMMR/MSI-H), its role in non-metastatic CRC is rapidly evolving.
Nicholas, Burley +11 more
openaire +2 more sources
Hochrisiko-Melanom: Rezidivprädiktion durch postoperative ctDNA
Im Focus Onkologie, 2018Nach Resektion eines Hochrisiko-Melanoms mit BRAF- oder NRAS-Mutation nachgewiesene zirkulierende Tumor-DNA ist ein praziser Rezidivpradiktor und damit fur die Patientenauswahl fur eine adjuvante Therapie geeignet.
openaire +1 more source
Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
exaly
PADA-1 trial: ESR1 mutations in plasma ctDNA guide treatment switching
Nature Reviews Clinical Oncology, 2022Ben O'Leary
exaly
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
Nature, 2023Christopher Abbosh +2 more
exaly
Post-surgical ctDNA in patients with CRC
Nature Reviews Gastroenterology & Hepatology, 2023openaire +2 more sources