Results 21 to 30 of about 47,434 (363)
Liquid Biopsy, ctDNA Diagnosis through NGS [PDF]
Life, 2021 Liquid biopsy with circulating tumor DNA (ctDNA) profiling by next-generation sequencing holds great promise to revolutionize clinical oncology. It relies on the basis that ctDNA represents the real-time status of the tumor genome which contains information of genetic alterations. Compared to tissue biopsy, liquid biopsy possesses great advantages such
Chen Lin +4 more
openaire +4 more sources
Identification of Genetic Alterations by Circulating Tumor DNA in Leiomyosarcoma: A Molecular Analysis of 73 Patients [PDF]
Journal of Immunotherapy and Precision Oncology, 2020 Background: Leiomyosarcoma is a malignant mesenchymal tumor of cells of smooth muscle lineage arising commonly in retroperitoneum, uterus, large veins, and the limbs.
Junaid Arshad +5 more
doaj +1 more source
Using cfDNA and ctDNA as Oncologic Markers: A Path to Clinical Validation
International Journal of Molecular Sciences, 2023 The detection of circulating tumor DNA (ctDNA) in liquid biopsy samples as an oncological marker is being used in clinical trials at every step of clinical management.
Jonathan Dao +5 more
semanticscholar +1 more source
Société Internationale d’Urologie Journal, 2023 None.
Manishkumar S. Patel, Liang Wang
doaj +1 more source
Review of precision cancer medicine: Evolution of the treatment paradigm. [PDF]
, 2020 In recent years, biotechnological breakthroughs have led to identification of complex and unique biologic features associated with carcinogenesis. Tumor and cell-free DNA profiling, immune markers, and proteomic and RNA analyses are used to identify ...
Fountzilas, Elena +3 more
core +1 more source
ctDNA as a novel and promising approach for cancer diagnosis
EXCLI Journal : Experimental and Clinical Sciences, 2023 Hepatocellular carcinoma (HCC) is one of the most prevalent forms of cancer worldwide. Therefore, it is essential to diagnose and treat HCC patients promptly.
Negin Biglari +4 more
doaj +1 more source
Cancer Biology & Medicine, 2019 As immunotherapy has gained increasing interest as a new foundation for cancer therapy, some atypical response patterns, such as pseudoprogression and hyperprogression, have garnered the attention of physicians. Pseudoprogression is a phenomenon in which
Wenxiao Jia +4 more
doaj +1 more source
Regulatory implications of ctDNA in immuno-oncology for solid tumors
Journal for ImmunoTherapy of Cancer, 2023 In the era of precision oncology, use of circulating tumor DNA (ctDNA) is emerging as a minimally invasive approach for the diagnosis and management of patients with cancer and as an enrichment tool in clinical trials.
P. Vellanki +9 more
semanticscholar +1 more source
Molecular response assessment using circulating tumor DNA (ctDNA) in advanced solid tumors
British Journal of Cancer, 2023 The therapeutic landscape for patients with advanced malignancies has changed dramatically over the last twenty years. The growing number of targeted therapies and immunotherapeutic options available have improved response rates and survival for a subset
Jeffrey C. Thompson +3 more
semanticscholar +1 more source
Impact of linker histone in the formation of ambochlorin-calf thymus DNA complex: Multi-spectroscopic, stopped-flow, and molecular modeling approaches [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): This study aimed to evaluate the role of the linker histone (H1) in the binding interaction between ambochlorin (Amb), and calf thymus DNA (ctDNA) as binary and ternary systems.
Azam Askari +8 more
doaj +1 more source