Results 31 to 40 of about 25,204 (165)

The Prognostic Importance of ctDNA in Rectal Cancer: A Critical Reappraisal

Cancers, 2022
The treatment of locally advanced rectal cancer (LARC) has evolved during the last decades, but recurrence remains a problem. Circulating tumor DNA (ctDNA) may result in an individualized treatment approach with improved survival and quality of life, but diverging results impede further development.
Edina Dizdarevic, Torben Hansen, Anders Jakobsen   +2 more
openaire   +3 more sources

Liquid Biopsy as a Minimally Invasive Source of Thyroid Cancer Genetic and Epigenetic Alterations [PDF]

International Journal of Molecular and Cellular Medicine, 2019
In the blood of cancer patients, some nucleic acid fragments and tumor cells can be found that make it possible to trace tumor changes through a simple blood test called “liquid biopsy”.
Fatemeh Khatami, Bagher Larijani, Shirzad Nasiri, Seyed Mohammad Tavangar   +3 more
doaj  

Cerebrospinal fluid circulating tumor DNA depicts profiling of brain metastasis in NSCLC

Molecular Oncology, 2023
Brain metastasis (BM) genetically diverges from the primary tumor in non‐small‐cell lung cancer (NSCLC). Hence, accurately capturing clinically relevant alterations is pivotal for the delivery of targeted therapies.
Jun Wu, Zhiqiang Liu, Tianxiang Huang, Ying Wang, Meng Meng Song, Tao Song, Gretchen Long, Xiaobing Zhang, Xi Li, Longbo Zhang   +9 more
doaj   +1 more source

Application of liquid biopsy in lung cancer management

Indian Journal of Pathology and Microbiology
Current advances in the understanding of the lung cancer landscape have drastically changed the approach to treating a patient with lung carcinoma. The field has progressed from analyzing single gene to using advanced techniques like next-generation ...
Shraddhanjali Satapathy, Balamurugan Thirunavukkarasu, Deepali Jain   +2 more
doaj   +1 more source

Clinical applications of circulating tumor DNA (ctDNA) as biomarker in gastric cancer [PDF]

Exploration of Digestive Diseases
Gastric cancer is one of the most prevalent malignancies of the gastrointestinal tract. Worldwide, it ranks as the fourth most commonly diagnosed cancer and the third leading cause of cancer-related mortality.
Sunil Vitthalrao Jagtap, Shubham S. Jagtap, Mohini S. Patil, Prayosha S. Thakkar   +3 more
doaj   +1 more source

ctDNA Reveals Targetable Alterations [PDF]

Cancer Discovery, 2020
Abstract In the plasmaMATCH trial, researchers performed circulating tumor DNA testing on patients with advanced breast cancer and matched those with ESR1, HER2, or AKT1 alterations to targeted therapies. Patients with HER2 and AKT1 mutations experienced response rates greater than 22% with durable benefit.
openaire   +1 more source

The potential of ctDNA analysis in breast cancer

Critical Reviews in Clinical Laboratory Sciences, 2019
Breast cancer is a highly heterogeneous and dynamic disease, exhibiting unique somatic alterations that lead to disease recurrence and resistance. Tumor biopsy and conventional imaging approaches are not able to provide sufficient information regarding the early detection of recurrence and real time monitoring through tracking sensitive or resistance ...
Tzanikou, E., Lianidou, E.
openaire   +3 more sources

Monitoring ctDNA RAS Mutational Status in Metastatic Colorectal Cancer: A Trial Protocol of RAS-trace and RAS-trace-2 Studies

Journal of the Anus, Rectum and Colon
Background: Spatial and temporal heterogeneities of RAS and other molecular genes should be considered in the treatment of metastatic colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs ...
Kozo Kataoka, Takeshi Yamada, Manabu Shiozawa, Naoto Takase, Kazuma Ito, Kentaro Yamazaki, Jun Watanabe, Toshihiro Kudo, Takeshi Suto, Toshihiko Matsumoto, Kohei Murata, Yusuke Suwa, Shogen Boku, Hisateru Yasui, Nobuhisa Matsuhashi, Atsuyuki Maeda, Kiichi Sugimoto, Yusuke Matsumoto, Mitsuru Yokota, Johannes Fredebohm, Keita Mori, Masataka Ikeda   +21 more
doaj   +1 more source

Circulating Tumor DNA in Primary and Secondary Liver Cancers: A Comprehensive Review

Frontiers in Bioscience-Scholar
Similar to many other cancer types, liver malignancies pose the common challenges of late detection of primary tumors and recurrences. Liquid biopsies, which assess the presence of circulating tumor DNA, have emerged as a novel, non-invasive clinical ...
Hanna Hong, Chase J Wehrle, Omer Faruk Karakaya, Noah Tocci, Pranav Kumar, Keyue Sun, Chunbao Jiao, Sangeeta Satish, Rebecca Panconesi, Jamak Modaresi Esfeh, Maureen Whitsett Linganna, Koji Hashimoto, Andrea Schlegel, Charles Miller, David C.H. Kwon, Federico Aucejo   +15 more
doaj   +1 more source

La integración de la prueba de ctDNA en el análisis de EGFR en el carcinoma pulmonar no microcítico: estrategias para el laboratorio clínico

Advances in Laboratory Medicine
El análisis molecular del gen receptor del factor de crecimiento epidérmico (EGFR) resulta fundamental a la hora de seleccionar una terapia dirigida para el carcinoma pulmonar no microcítico avanzado (CPNM).
Fernández-Galán Esther, Puig-Butillé Joan Anton   +1 more
doaj   +1 more source