Results 51 to 60 of about 25,204 (165)

Monitoring ctDNA in aggressive B-cell lymphoma: a prospective correlative study of ctDNA kinetics and PET-CT metrics [PDF]

Blood Advances
Abstract Positron emission tomography–computed tomography (PET-CT) is recommended for response evaluation in aggressive large B-cell lymphoma (LBCL) but cannot detect minimal residual disease (MRD). Circulating tumor DNA (ctDNA) has emerged as a promising biomarker for real-time disease monitoring.
Gayaththri Vimalathas, Marcus Høy Hansen, Oriane Cédile, Mads Thomassen, Michael Boe Møller, Sara Kamuk Dahlmann, Marie Louise Grube Kjeldsen, Malene Grubbe Hildebrandt, Anne Lerberg Nielsen, Mohammad Naghavi-Behzad, Lars Edenbrandt, Charlotte Guldborg Nyvold, Thomas Stauffer Larsen   +12 more
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Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer

Journal of Hematology & Oncology, 2019
Background Treatment outcomes for patients with advanced pancreatic ductal adenocarcinoma (PDAC) remain dismal. There are unmet needs for understanding the biologic basis of this malignancy using novel next-generation sequencing technologies.
Hitendra Patel, Ryosuke Okamura, Paul Fanta, Charmi Patel, Richard B. Lanman, Victoria M. Raymond, Shumei Kato, Razelle Kurzrock   +7 more
doaj   +1 more source

Circulating tumor DNA in patients with cancer: insights from clinical laboratory

Advances in Laboratory Medicine
Blood-based circulating tumor DNA (ctDNA) analysis has emerged as a highly relevant non-invasive method for molecular profiling of solid tumors, offering valuable information about the genetic landscape of cancer.
Illana Francisco J., Fernández-Galán Esther, Muñoz-Bravo José Luis, Valiña Amado Laura, García Martín Carme, González-Fernández Carolina, Miró-Cañís Sílvia, Trapé Jaume, Martínez-Peinado Antonio, Filella Xavier, González Alvaro, Sánchez Antonio Barco, Díaz-Lagares Angel,   +13 more
doaj   +1 more source

Circulating tumor DNA (ctDNA) Detection via electrochemical Biosensing Tools

MANAS: Journal of Engineering
Cancer is characterized by the presence of mutated alleles in DNA, leading to the formation of tumors. A delayed diagnosis of this condition can result in fatal outcomes, making it a significant global cause of mortality.
Sonya Sahin, Nimet Yıldırım Tirgil
doaj   +1 more source

Association of clinical-morphological and molecular-genetic factors (mutations in GNAQ and GNA11 oncogenes and АBСB1 gene polymorphism) in patients with iris melanoma

Российский офтальмологический журнал
Purpose: to analyze the frequency of GNAQ/GNA11 mutations in circulating tumor DNA and tumor tissue, and the frequency of genotypes of polymorphic marker C3435T of ABCB1 gene in patients with iris melanoma. Material and methods.
S. V. Saakyan, I. V. Svirina, A. Yu. Tsygankov, A. M. Burdennyi, V. I. Loginov   +4 more
doaj   +1 more source

ctDNA SNORD3F Hypermethylation is a Prognostic Indicator in EGFR-TKI-Treated Advanced Non-Small Cell Lung Cancer

Cancer Management and Research
Bin Liu,* Bingtian Zhao,* Yan Yin, Yan Jiang, Xue Feng, Lei Wang, Liang Zhai, Guangxin Liu, Dongsheng Shi, Jianwen Qin Department of Respiratory and Critical Medicine, Tianjin Chest Hospital, Tianjin, People’s Republic of China*These authors ...
Liu B, Zhao B, Yin Y, Jiang Y, Feng X, Wang L, Zhai L, Liu G, Shi D, Qin J   +9 more
doaj  

Concept and feasibility of the Augsburg Longitudinal Plasma Study (ALPS) – a prospective trial for comprehensive liquid biopsy-based longitudinal monitoring of solid cancer patients

Journal of Laboratory Medicine
Liquid biopsy (LBx) provides diagnostic, prognostic and predictive insights for malignant diseases and offers promising applications regarding tumor burden, tumor heterogeneity and clonal evolution.
Sommer Sebastian, Schmutz Maximilian, Hildebrand Kathrin, Schiwitza Annett, Benedikt Selinah, Eberle Maria, Mögele Tatiana, Sultan Aziz, Reichl Lena, Campillo Maria, Uhrmacher Luise, Nikolic Ana Antic, Bundschuh Ralph, Lapa Constantin, Kuhlen Michaela, Dintner Sebastian, Langer Angela, Märkl Bruno, Wendler Thomas, Tehlan Kartikay, Kröncke Thomas, Wahle Maria, Mann Matthias, Casadei Nicolas, Pogoda Michaela, Hummler Simone, Sax Irmengard, Schlesner Matthias, Kubuschok Boris, Trepel Martin, Claus Rainer   +30 more
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Appropriate Duration of First-line Immunotherapy for 
Advanced NSCLC and Predictive Factors

Chinese Journal of Lung Cancer
First-line immunotherapy for advanced non-small cell lung cancer (NSCLC) shows significant survival benefits in patients without driver mutations, but the optimal duration of treatment remains controversial. Some studies support limiting immunotherapy to
Yue YIN, Xiaotong GUO, Jing AI, Jibo YUE, Lili DENG   +4 more
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ADN tumoral circulante en pacientes con cáncer: perspectivas desde el laboratorio clínico

Advances in Laboratory Medicine
El análisis de ADN tumoral circulante (ctDNA) es un método no invasivo de gran relevancia para la caracterización molecular de los tumores sólidos, que aporta información valiosa sobre el perfil genético del cáncer. Actualmente, el análisis de mutaciones
Illana Francisco J., Fernández-Galán Esther, Muñoz-Bravo José Luis, Amado Laura Valiña, García Martín Carme, González-Fernández Carolina, Miró-Cañís Sílvia, Trapé Jaume, Martínez-Peinado Antonio, Filella Xavier, González Alvaro, Barco Sánchez Antonio, Díaz-Lagares Angel,   +13 more
doaj   +1 more source

ctDNA predicts outcomes in DLBCL [PDF]

Nature Reviews Clinical Oncology, 2018
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