Results 61 to 70 of about 36,124 (280)

The potential for liquid biopsies in the precision medical treatment of breast cancer. [PDF]

, 2016
Currently the clinical management of breast cancer relies on relatively few prognostic/predictive clinical markers (estrogen receptor, progesterone receptor, HER2), based on primary tumor biology.
Barrak, Dany K, Elhodaky, Mostafa, Forte, Victoria A, Lang, Julie E, Snow, Anson, Tung, Lily   +5 more
core   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

A single digital droplet PCR assay to detect multiple KIT exon 11 mutations in tumor and plasma from patients with gastrointestinal stromal tumors [PDF]

, 2018
__Background:__ Gastrointestinal stromal tumors (GISTs) are characterized by oncogenic KIT mutations that cluster in two exon 11 hotspots. The aim of this study was to develop a single, sensitive, quantitative digital droplet PCR (ddPCR) assay for the ...
Atriafi, F. (Florence), Boonstra, P.A. (André), Bosman, L.J. (Lisette J.), Coevorden, F. (Frits) van, Desar, I.M.E. (Ingrid), Elst, A. (Arja) ter, Farag, S. (Sheima), Gelderblom, H. (Hans), Gietema, J.A. (Jourik), Graaf, W.T.A. (Winette) van der, Maier, J. (Jacqueline), Mathijssen, A.H.J. (Ron), Overbosch, J. (Jelle), Reyners, A.K.L. (Anna), Schuuring, E. (Ed), Steeghs, N. (Neeltje), Suurmeijer, A.J.H. (Albert J. H.), Tibbesma, M. (Marco)   +17 more
core   +1 more source

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

Prognostic Value of Postoperative Circulating Tumor DNA in Patients With Early- and Intermediate-Stage Hepatocellular Carcinoma

Frontiers in Oncology, 2022
Majority of patients with resected early- and intermediate-stage liver cancer will experience postoperative recurrence. This study aimed to investigate the application of ctDNA sequencing in the postoperative period of hepatocellular carcinoma.
Ke Ye, Qinqiao Fan, Mingming Yuan, Dong Wang, Liang Xiao, Guo Long, Rongrong Chen, Tongdi Fang, Zengbo Li, Ledu Zhou   +9 more
doaj   +1 more source

The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review [PDF]

, 2017
Background: The presence of circulating cell-free DNA from tumours in blood (ctDNA) is of major importance to those interested in early cancer detection, as well as to those wishing to monitor tumour progression or diagnose the presence of activating ...
A Castagnaro, A Melnikov, A Szpechcinski, AM Mazurek, AM Newman, Angela Cox, Anne Reiman, AR Thierry, B Gong, B Taback, Becky L. Whiteman, BH Kim, C Bettegowda, C Chiappetta, C Kneip, CF Eisenberger, CH Metz, CP Lange, D Hanahan, D Madhavan, Dawn Teare, DM Hyman, DM Kurtz, E Cassinotti, E Crowley, E Danese, E Heitzer, E Heitzer, E Kirkizlar, E Papadopoulou, E Zonta, ER Zaher, EY Rykova, F Andriani, F Diehl, F Perrone, F Salvianti, F Tian, G Huang, G Sharma, G Sozzi, G Weiss, Helen Buckley Woods, HS Hsu, Hugh Kikuchi, I Andolfo, I Ibanez de Caceres, I Skrypkina, IA Cree, IA Cree, Ian A. Cree, J Belic, J Ellinger, J Martinez-Galan, J Melson, J Tabernero, J Uchida, Jacqui Shaw, JD Warren, JM Yi, JY Wang, K Page, K Page, K Sikora, K Toth, K Warton, KL Aung, KL Spindler, L Benesova, L Chen, L De Mattos-Arruda, L Fernandez-Cuesta, L Sorber, L Uttley, Lesley Uttley, LS Kristensen, M Agostini, M Chimonidou, M Chimonidou, M de Martino, M Seefeld, M Shan, M Zane, MB Freidin, Michael Messenger, MJ Duffy, MO Hoque, NA Mohamed, NT Potter, Orla Sheils, P Jin, P Xia, PJ Johnson, PM Bossuyt, Q Zhang, QT Zhao, R Divella, R Dumache, R Grutzmann, R Mead, R Minciu, R Radpour, RA Zanetti-Dallenbach, RF Andersen, S Begum, S Couraud, S Hauser, S Kurihara, S McPhail, S Salvi, SC Pack, Sian Taylor Philips, SK Kadam, SR Payne, Susan Harnan, T deVos, T Powrozek, T Powrozek, TB Hao, TE Skvortsova, TR Church, U Ladabaum, V Kloten, V Swarup, X Lou, X Shao, XY Zhong, Y Zhang, YB Kuo, YJ Yang, YJ Zhang, YM Lo, YM Lo, YM Lo   +133 more
core   +3 more sources

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Application of liquid biopsy in lung cancer management

Indian Journal of Pathology and Microbiology
Current advances in the understanding of the lung cancer landscape have drastically changed the approach to treating a patient with lung carcinoma. The field has progressed from analyzing single gene to using advanced techniques like next-generation ...
Shraddhanjali Satapathy, Balamurugan Thirunavukkarasu, Deepali Jain   +2 more
doaj   +1 more source

Chloroplast DNA Copy Number Changes during Plant Development in Organelle DNA Polymerase Mutants [PDF]

, 2016
Chloroplast genome copy number is very high in leaf tissue, with upwards of 10,000 or more copies of the chloroplast DNA (ctDNA) per leaf cell. This is often promoted as a major advantage for engineering the plastid genome, as it provides high gene copy ...
Brent L. Nielsen, Stewart A. Morley
core   +2 more sources

A Dual‐Channel Synergistic Ultrasensitive Biosensor for Tumor Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Liquid biopsy technology, which detects circulating tumor DNA (ctDNA) in cerebrospinal fluid, plays a crucial role in the early diagnosis and precision treatment of gliomas. However, the intrinsically low abundance and rapid clearance of ctDNA pose substantial challenges for conventional analytical techniques, such as droplet digital PCR and ...
Yu Sun, Jing Zhang, Chenqing Liu, Jing Lou, Sihui Wang, Xiangtian Ji, Xiaofang Zhao, Shirui Xu, Jingyu Feng, Bin Liu, Chao Chang, Qinggang Ge, Jun Yang   +12 more
wiley   +1 more source