Results 61 to 70 of about 39,021 (326)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Interstrand DNA covalent binding of two dinuclear Ru(ii) complexes. Influence of the extra ring of the bridging ligand on the DNA interaction and cytotoxic activity [PDF]

, 2017
In this work, we report experimental and computational evidences for the intercalation into the DNA base pairs of the free quinones Quinizarin (Q), Naphthazain (N) and the interstrad covalent binding of their p-cymene di-Ruthenium(II) complexes (Cl2Ru2X,
Busto, Natalia, Carbayo, Arancha, Espino, Gustavo, García, Begoña, Leal, José M., Lozano, Héctor J., Platts, James   +6 more
core   +2 more sources

1640P Response monitoring with ctDNA in metastatic pancreatic cancer [PDF]

, 2023
Jong‐Hwa Ahn, Kwangrok Jung, J. Lee, B. Kim, JC Lee, Ji Hoon Kim, J-H. Hwang   +6 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Preoperative image-guided identification of response to neoadjuvant chemoradiotherapy in esophageal cancer (PRIDE):a multicenter observational study [PDF]

, 2018
BACKGROUND: Nearly one third of patients undergoing neoadjuvant chemoradiotherapy (nCRT) for locally advanced esophageal cancer have a pathologic complete response (pCR) of the primary tumor upon histopathological evaluation of the resection specimen ...
, Bartels-Rutten, A., Beets-Tan, R. G. H., Bennink, R. J., Bergman, J. J., Borggreve, A. S., Brosens, L. A. A., Defize, I. L., Dijkstra, H., Henegouwen, M. I. van Berge, Hulshof, M. C., Lam, M. G. E. H., Meijer, G. J., Mook, S., Muijs, C. T., Mul, V. E. M., Nagengast, W. B., Nederveen, A. J., Noordzij, W., Plukker, J. T. M., Ruurda, J. P., ter Beek, L. C., van Dieren, J. M., van Hillegersberg, R., van Laarhoven, H. W. M., van Lier, A. L. H. M. W., van Rossum, P. S. N., van Sandick, J. W., Verheij, M., Voncken, F. E. M., Weusten, B. L. A. M., Yakar, D.   +31 more
core   +4 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Profiling lung adenocarcinoma by liquid biopsy: can one size fit all? [PDF]

, 2016
BACKGROUND: Cancer is first and foremost a disease of the genome. Specific genetic signatures within a tumour are prognostic of disease outcome, reflect subclonal architecture and intratumour heterogeneity, inform treatment choices and predict the ...
Cassidy, Amy P, Cassidy, John W, Clifford, Harry W, Hewage, Emil, O'Neill, Hannah L, Patel, Nirmesh, Seres, Bianka, Tsai, Evaline S, Vaughn, Courtney   +8 more
core   +2 more sources

Targets, pitfalls and reference materials for liquid biopsy tests in cancer diagnostics [PDF]

, 2020
Assessment of cell free DNA (cfDNA) and RNA (cfRNA), circulating tumor cells (CTC) and extracellular vesicles (EV) in blood or other bodily fluids can enable early cancer detection, tumor dynamics assessment, minimal residual disease detection and ...
Geeurickx, Edward, Hendrix, An
core   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

High fragmentation characterizes tumour-derived circulating DNA. [PDF]

PLoS ONE, 2011
BACKGROUND: Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cancers including colorectal cancer, especially when considering the detection of mutations.
Florent Mouliere, Bruno Robert, Erika Arnau Peyrotte, Maguy Del Rio, Marc Ychou, Franck Molina, Celine Gongora, Alain R Thierry   +7 more
doaj   +1 more source