Results 111 to 120 of about 436,571 (380)

Virus infection pattern imprinted and diversified the differentiation of T-cell memory in transcription and function

Frontiers in Immunology
IntroductionMemory T (Tm) cells are a subpopulation of immune cells with great heterogeneity. Part of this diversity came from T cells that were primed with different viruses.
Yuan Wang, Yuan Wang, Xinyue Mei, Zhengfang Lin, Xiaoyun Yang, Xiaoyun Yang, Jinpeng Cao, Jinpeng Cao, Jiaying Zhong, Junxiang Wang, Li Cheng, Zhongfang Wang, Zhongfang Wang   +12 more
doaj   +1 more source

Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response

PLoS Pathogens, 2009
Human lymphocyte antigen (HLA)-restricted CD8+ cytotoxic T lymphocytes (CTL) target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fitness.
R. Troyer, J. McNevin, Yi Liu, S. Zhang, Randall W. Krizan, Awet Abraha, D. Tebit, Hong-ring Zhao, Santiago Avila, M. Lobritz, M. McElrath, S. Le Gall, J. Mullins, E. Arts   +13 more
semanticscholar   +1 more source

Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. [PDF]

, 2003
CD8+ class I-restricted cytotoxic T lymphocytes (CTLs) usually incompletely suppress HIV-1 in vivo, and while analogous partial suppression induces antiretroviral drug-resistance mutations, epitope escape mutations are inconsistently observed.
Ali, Ayub, Brander, Christian, Harlow, Jason D, Kalams, Spyros A, Sarkis, Phuong Thi Nguyen, Walker, Bruce D, Yang, Otto O   +6 more
core  

Recent Advances in Wide‐Bandgap Perovskite Solar Cells

Advanced Materials, EarlyView.
Ubiquitous defects predominately account for photo‐instability and open‐circuit voltage losses in wide‐bandgap perovskite solar cells (WBG PSCs). This review comprehensively presents the underlying impact mechanisms, summarizes the advanced optimization strategies across various functional layers and their interfaces to develop efficient and stable WBG
Jianjun Mei, Feng Yan
wiley   +1 more source

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

Journal of Immunotherapy for Cancer, 2015
UNLABELLED We examined the immune microenvironment of primary colorectal cancer using immunohistochemistry, laser capture microdissection/qRT-PCR, flow cytometry, and functional analysis of tumor-infiltrating lymphocytes.
Nicolas J. Llosa, M. Cruise, A. Tam, Elizabeth C Wicks, Elizabeth M. Hechenbleikner, J. Taube, R. Blosser, H. Fan, Hao Wang, Brandon S. Luber, Ming Zhang, N. Papadopoulos, K. Kinzler, B. Vogelstein, C. Sears, R. Anders, D. Pardoll, F. Housseau   +17 more
semanticscholar   +1 more source

ctl with finitely bounded semantics

, 2017
We consider a variation of the branching time logic CTL with non-standard, "finitely bounded" semantics (FBS).
Goranko, Valentin, Kuusisto, Antti, Rönnholm, Raine   +2 more
openaire   +5 more sources

Nanostructured Protein Surfaces Inspired by Spider Silk

Advanced Materials, EarlyView.
Harnessing recombinant spider silk technology, bioengineered spidroin variants enable the creation of functionalized nanostructured coatings with tunable affinity for specific targets, supporting a broad range of applications ‐ from antifouling surfaces and targeted drug delivery to advanced cell therapies and precision bio‐patterning via lithography ...
Martin Humenik, Thomas Scheibel
wiley   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Disulfidptosis characterizes the tumor microenvironment and predicts immunotherapy sensitivity and prognosis in bladder cancer

Heliyon
Background: Bladder cancer (BLCA) is prone to metastasis and has poor prognosis with unsatisfactory treatment responsiveness. Disulfidptosis is a recently discovered, novel mode of cell death that is closely associated with human cancers.
Guizhen Pan, Huan Xie, Yeye Xia
doaj   +1 more source

Host immune response to cytomegalovirus [PDF]

, 1987
To confirm that immediate-early (IE) genes of murine cytomegalovirus (MCMV) give rise to antigens recognized by specific cytolytic T lymphocytes (CTL), a 10.8-kilobase fragment of MCMV DNA which is abundantly transcribed at IE times was transfected into ...
Keil, Günther M., Koszinowski, Ulrich H., Reddehase, Matthias J., Schickedanz, Jörg   +3 more
core