Results 121 to 130 of about 399,115 (333)

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach

Biomedicines
Immunotherapy is now established as a potent therapeutic paradigm engendering antitumor immune response against a wide range of malignancies and other diseases by modulating the immune system either through the stimulation or suppression of immune ...
Subhamay Adhikary, Surajit Pathak, Vignesh Palani, Ahmet Acar, Antara Banerjee, Nader I. Al-Dewik, Musthafa Mohamed Essa, Sawsan G. A. A. Mohammed, M. Walid Qoronfleh   +8 more
doaj   +1 more source

Hyper Parametric Timed CTL

IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Hyperproperties enable simultaneous reasoning about multiple execution traces of a system and are useful to reason about non-interference, opacity, robustness, fairness, observational determinism, etc. We introduce hyper parametric timed computation tree logic (HyperPTCTL), extending hyperlogics with timing reasoning and, notably, parameters to express
Masaki Waga, Étienne André
openaire   +2 more sources

DEVELOPMENT OF CTL-BASED PERFORMANCE ASSESSMENT INSTRUMENTS ON SIMPLE HARMONIC MOTION TOPIC

, 2022
Fisa Wisnu Wijaya, Taufiqqurachman Taufiqqurachman, Moch. Arief Sutisna   +2 more
openalex   +2 more sources

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Arming CTLs against immunosuppressors

Blood, 2009
Cell therapy efficacy after organ transplantation is hampered by the detrimental effects of pharmacologic immunosuppression on T-cell expansion and function. In this issue of Blood , 2 independent groups describe genetic engineering of ex vivo expanded EBV-CTLs to induce calcineurin-inhibitor resistance.
openaire   +3 more sources

New results on pushdown module checking with imperfect information

, 2011
Model checking of open pushdown systems (OPD) w.r.t. standard branching temporal logics (pushdown module checking or PMC) has been recently investigated in the literature, both in the context of environments with perfect and imperfect information about ...
A. Bouajjani, A. Ferrante, A.K. Chandra, B. Aminof, E.M. Clarke, Giovanna D'Agostino, I. Walukiewicz, I. Walukiewicz, J.E. Hopcroft, J.H Reif, K. Chatterjee, L. Bozzelli, L. Bozzelli, L. Bozzelli, Laura Bozzelli, O. Kupferman, O. Kupferman, O. Kupferman, O. Kupferman, R. Alur, Salvatore La Torre, T. Ball   +21 more
core   +2 more sources

Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming [PDF]

, 2006
Rhys S. Allan, Jason Waithman, Sammy Bedoui, Claerwen M. Jones, Jóse A. Villadangos, Yifan Zhan, Andrew M. Lew, Ken Shortman, William R. Heath, Federico Carbone   +9 more
openalex   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Induction of HLA-A2-restricted CTLs to the mucin 1 human breast cancer antigen. [PDF]

, 1997
Vasso Apostolopoulos, Vaios Karanikas, John S. Haurum, Ian F. C. McKenzie   +3 more
openalex   +1 more source