Results 141 to 150 of about 436,571 (380)

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

A diversity of novel type-2 innate lymphoid cell subpopulations revealed during tumour expansion

Communications Biology
Type 2 innate lymphoid cells (ILC2s) perform vital functions in orchestrating humoral immune responses, facilitating tissue remodelling, and ensuring tissue homeostasis.
Clara Wenjing Xia, Iryna Saranchova, Pablo L. Finkel, Stephanie Besoiu, Lonna Munro, Cheryl G. Pfeifer, Anne Haegert, Yen-Yi Lin, Stéphane Le Bihan, Colin Collins, Wilfred A. Jefferies   +10 more
doaj   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy

Acta Pharmaceutica Sinica B
A major challenge facing photodynamic therapy (PDT) is that the activity of the immune-induced infiltrating CD8+ T cells is subject to the regulatory T lymphocytes (Tregs), leaving the tumor at risk of recurrence and metastasis after the initial ablation.
Siqin He, Lulu Wang, Dongxu Wu, Fan Tong, Huan Zhao, Hanmei Li, Tao Gong, Huile Gao, Yang Zhou   +8 more
doaj   +1 more source

Activation of virus specific CTL clones: antigen-dependent regulation of interleukin 2 receptor expression. [PDF]

, 1985
M E Andrew, Albert M. Churilla, Thomas R. Malek, V L Braciale, Thomas J. Braciale   +4 more
openalex   +1 more source

On the Complexity of ATL and ATL* Module Checking

, 2017
Module checking has been introduced in late 1990s to verify open systems, i.e., systems whose behavior depends on the continuous interaction with the environment.
Bozzelli, Laura, Murano, Aniello
core   +1 more source

The CXCL10‐CXCR3 Axis Induces Tumor‐Associated Neutrophils to Interfere with CTLs‐Mediated Antitumor Activity in EBV‐Associated Epithelial Cancers

Advanced Science, EarlyView.
Compared with EBV‐negative epithelial cancer cells, EBV‐associated epithelial cancer cells exhibit enhanced secretion of chemokines, including CXCL10 and CCL5, to attract neutrophils. Via the CXCL10‐CXCR3 axis‐mediated positive feedback loop, neutrophils within EBV‐associated epithelial cancer cells are induced to form abundant NETs, which facilitate ...
Dijun Ouyang, Tong Xiang, Yuanyuan Chen, Mengjia Song, Jingjing Zhao, Hao Chen, Si Li, Lifeng Zhang, Chi Xu, Yan Ren, Yong Tao, Qijing Wang, Jia He, Yongqiang Li, Sisi Xie, Yuanyuan Liu, Yan Wang, Xinyi Yang, Jinqi You, Songzuo Xie, Yingzi Li, Desheng Weng, Qiuzhong Pan, Qi Yang, Jianchuan Xia   +24 more
wiley   +1 more source

Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach

Biomedicines
Immunotherapy is now established as a potent therapeutic paradigm engendering antitumor immune response against a wide range of malignancies and other diseases by modulating the immune system either through the stimulation or suppression of immune ...
Subhamay Adhikary, Surajit Pathak, Vignesh Palani, Ahmet Acar, Antara Banerjee, Nader I. Al-Dewik, Musthafa Mohamed Essa, Sawsan G. A. A. Mohammed, M. Walid Qoronfleh   +8 more
doaj   +1 more source

The T cell receptor from an influenza-A specific murine CTL clone [PDF]

, 1989
Mark S. Palmer, Ann Bentley, Keith G. Gould, Alian R.M. Townsend   +3 more
openalex   +1 more source

Hybrid Branching-Time Logics

, 2007
Hybrid branching-time logics are introduced as extensions of CTL-like logics with state variables and the downarrow-binder. Following recent work in the linear framework, only logics with a single variable are considered.
Weber, Volker
core   +1 more source