Results 151 to 160 of about 329,027 (236)

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

open access: yesEpilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Integrated Multiomics Analyses of the Molecular Landscape of Sarcopenia in Alcohol-Related Liver Disease. [PDF]

open access: yesJ Cachexia Sarcopenia Muscle
Welch N   +14 more
europepmc   +1 more source

Optical Study and Numerical Simulation of the Effect of n‐butanol Mass on the Combustion Process of a n‐butanol/Diesel Dual‐Fuel Engine

open access: yesEnergy Science &Engineering, EarlyView.
An optical engine testing platform has been built. The influence of n‐butanol mass on the combustion process was studied in the RCCI combustion mode using intake injection of n‐butanol and direct injection of diesel in the cylinder. Using high‐speed imaging technology to capture the combustion process inside the cylinder, the dual color method is used ...
Wei Mingrui, Zhou Qian, Liu Jinping
wiley   +1 more source

Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials

open access: yesExploration, EarlyView.
Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu   +4 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of the Immune Response to COVID‐19 and Tuberculosis Coinfection

open access: yesExploration, EarlyView.
Understanding the immunological basis for severe outcomes in COVID‐19/Tuberculosis coinfection is critical. Our single‐cell analysis identifies key drivers: profound lymphocyte loss through combined apoptosis and altered trafficking, excessive S100 protein‐mediated inflammation contributing to cytokine storms, and systemic immune dysfunction ...
Yi Wang   +20 more
wiley   +1 more source

Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer

open access: yesExploration, EarlyView.
Considering the rapid progression of cancer in most cases, any delay in evaluating therapy outcomes poses a significant threat to patients’ lives. Consequently, it is imperative to implement stratification and conduct timely evaluations of therapeutic effects either before or during the early stages of cancer treatment.
Qinrui Fu
wiley   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

open access: yesExploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang   +6 more
wiley   +1 more source

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