Results 181 to 190 of about 436,571 (380)
c-fos transcriptional activation by IL-2 in mouse CTL-L2 cells is mediated through two distinct signal transduction pathways converging on the same enhancer element. [PDF]
, 1991 Didier Trouche +4 more
openalex +1 more source
Arming CTLs against immunosuppressors
Blood, 2009 Cell therapy efficacy after organ transplantation is hampered by the detrimental effects of pharmacologic immunosuppression on T-cell expansion and function. In this issue of Blood , 2 independent groups describe genetic engineering of ex vivo expanded EBV-CTLs to induce calcineurin-inhibitor resistance.
openaire +4 more sources
From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies
Advanced Science, EarlyView.This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen +7 more
wiley +1 more source
Heterogeneous mechanisms of human cytotoxic T lymphocyte generation. II. Differential effects of IL-6 on the helper cell-independent generation of CTL from CD8+ precursor subpopulations. [PDF]
, 1993 H Z Bass +2 more
openalex +1 more source
Advanced Science, EarlyView.This study identifies that RBM10 represses the transcriptional activity of RORB in liquid condensates, resulting in down‐regulation of NR1D1 and RIOK3 that further activates NF‐κB activity to facilitate lysosomal biogenesis and aggressive features of NB cells.
Yanhua Guo +9 more
wiley +1 more source
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.
Journal of Clinical Investigation, 2014 C. Bauer +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.Co‐administration with MHC class I‐ and II‐restricted neoantigens encoding mRNA‐based personalized cancer vaccines in a mouse CRC model can induce antigen‐specific immune responses and anti‐cancer effects. Notably, vaccination at an early stage of cancer development can have potent anti‐cancer effects. Furthermore, combining mRNA with immune checkpoint
Seongje Cho +26 more
wiley +1 more source
332 MEASLES IN VACCINATED HIGHSCHOOLCHILDREN AS EVIDENCED BY SPECIFIC CYTOTOXIC T CELL (CTL) AND IgA RESPONSES [PDF]
, 1994 Robert S. van Binnendijk +4 more
openalex +1 more source
Advanced Science, EarlyView.Tan et al. developed a platelet membrane‐coated, thermoresponsive liposome for targeted, light‐controlled delivery of fluorinated peptides that promotes programmed death‐ligand 1 degradation, induces tumor immunogenic cell death, suppresses solid tumors and metastases, and triggers durable immune memory, offering a promising strategy for peptide‐based ...
Manman Tan +19 more
wiley +1 more source