Results 191 to 200 of about 180,278 (321)
The Structural Biology of T-Cell Antigen Detection at Close Contacts. [PDF]
Immunol RevLui Y +5 more
europepmc +1 more source
Identification of HLA-A*0201-restricted CTL epitopes encoded by the tumor-specificMAGE-2 gene product [PDF]
, 1997 Marjan J.W. Visseren +8 more
openalex +1 more source
Role of radiotherapy in surgical approaches to pancreatic cancer treatment: A narrative review
Annals of Gastroenterological Surgery, EarlyView.This review explores the role of radiotherapy (RT) in the multidisciplinary treatment of pancreatic ductal adenocarcinoma (PDAC), focusing on its integration with surgical strategies to improve resectability, local control, and survival outcomes while addressing potential challenges and future research directions.
Satoshi Yasuda +4 more
wiley +1 more source
Planar Tetracoordinate Oxygen Atoms
Angewandte Chemie, EarlyView.This study investigates 515 candidate structures featuring a planar tetracoordinate oxygen (ptO) atom, adhering to the 18 valence electron rule and formulated as OXnYmq. Among these, 35 global minima were identified, primarily stabilized by Group 13 elements with charge states spanning −1 to +1.
Gabriela Castillo‐Toraya +5 more
wiley +2 more sources
TP53‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, EarlyView.ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah +2 more
wiley +1 more source
Antigen targeting to dendritic cells: Still a place in future immunotherapy?
European Journal of Immunology, Volume 52, Issue 12, Page 1909-1924, December 2022., 2022 Dendritic cell‐based immunotherapy is a promising vaccination strategy to treat infectious diseases, autoimmunity, and cancer. In this review, we present an overview on the current state of antigen targeting approaches via C‐type lectin receptors, with an outlook on future developments and potential for clinical translation.
Patrizia Stoitzner +4 more
wiley +1 more source
Covalent Linkage to β2-Microglobulin Enhances the MHC Stability and Antigenicity of Suboptimal CTL Epitopes [PDF]
, 1999 Robert A. Uger +2 more
openalex +1 more source
Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives
American Journal of Hematology, EarlyView.ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley +1 more source
European Journal of Immunology, Volume 52, Issue 12, Page 1880-1888, December 2022., 2022 Somatic cells (fibroblasts, dendritic cells, T cells) are reprogrammed into induced pluripotent stem cells (iPS cells) with specific transcription factors. iPS cells are then differentiated into iPS cell‐derived DC (ipDC) with DC inducing cytokines. Fibroblasts are directly reprogrammed into induced DC (iDC) by DC specific transcription factors (direct
Niclas Flosdorf, Martin Zenke
wiley +1 more source