Results 241 to 250 of about 399,115 (333)

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

Upaya Meningkatkan Minat Belajar Peserta Didik dalam Pembelajaran IPA Melalui Pendekatan Pembelajaran Contextual Teaching And Learning (CTL) pada Kelas VII F di SMP Negeri 11 Surakarta

Dhimas Adha Raditya Rahmajati, Ketut Liana Arya Dewi   +1 more
openalex   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, EarlyView.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Recent Progress and Opportunities in Oxide Semiconductor Devices for In‐Memory and Neuromorphic Computing

Advanced Electronic Materials, EarlyView.
This review surveys oxide‐semiconductor devices for in‐memory and neuromorphic computing, highlighting recent progress and remaining challenges in charge‐trap, ferroelectric, and two‐transistor devices. Oxide semiconductors, featuring ultra‐low leakage, low‐temperature processing, and back‐end‐of‐line compatibility, are explored for analog in‐memory ...
Suwon Seong, Taejun Ha, Sangwook Jung, Wontae Jeong, Yoonyoung Chung   +4 more
wiley   +1 more source

Tandem Takeoff: Powering Tomorrow with Industrial‐Grade Perovskite/Silicon Solar Cells

Advanced Energy Materials, EarlyView.
Perovskite/silicon tandem solar cells have recently achieved certified power conversion efficiencies of 34.85%, far exceeding the Shockley‐Queisser limit for single‐junction silicon and standalone perovskite cells. This review highlights the latest advances in the design, integration, and optimization of perovskite top cells for monolithic tandem ...
Maria Vasilopoulou, Di Huang, Jue Gong, Faming Li, Hao Zhang, Yinqing Sun, Lin Mao, Ermioni Polydorou, Ioannis G. Aviziotis, Leonidas C. Palilis, Onurcan Kaya, Stephan Roche, Jordi Arbiol, Dimitrios Davazoglou, Emmanuel Kymakis, Lei Liu, Kuan Sun, Abd Rashid bin Mohd Yusoff, Mingzhen Liu, Mohammad Khaja Nazeeruddin   +19 more
wiley   +1 more source

CTL Diesel

, 2013
openaire   +2 more sources

IMPLEMENTASI MODEL PEMBELAJARAN CONTEXTUAL TEACHING and LEARNING (CTL) DALAM MENINGKATKAN HASIL BELAJAR SISWI KELAS XI PADA MATERI SISTEM KOLOID DI SMA ISLAM DARUL MUHIBBIEN BINUANG

Susilawati Susilawati, Rr. Ariessanty Alicia Kusuma Wardhani, Antoni Pardede   +2 more
openalex   +2 more sources

Lymphocyte-polarized dendritic cells are highly effective in inducing tumor-specific CTLs

, 2012
Erik Berk, Ravikumar Muthuswamy, Paweł Kaliński   +2 more
openalex   +2 more sources