Results 251 to 260 of about 436,571 (380)

AP2M1 Amplification Orchestrates Notch‐Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients

Advanced Science, EarlyView.
The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee, Eun Kyoung Kim, Hee Young Ju, Chae Rin Lee, Soyul Ahn, Eun‐Sun Kim, Kyungjae Myung, Won Kyu Kim, Su‐Yeon Cho, Yujin Kwon, Dokyoung Kim, Yeuni Yu, Eun Jung Kwon, Hyomin Kim, Seong Ik Mun, Dong Min Lim, Kihun Kim, Hye Jin Heo, Seung Eun Baek, Sun Young Lee, Hyunsoo Cho, Eun Young Choi, Tae Sik Goh, Ninib Baryawno, Dongjun Lee, Ki Sun Jung, Keon Hee Yoo, Chang‐Kyu Oh, Yun Hak Kim   +28 more
wiley   +1 more source

Immune Surveillance and Immune Escape in Cancer: Mechanisms and Immunotherapy. [PDF]

MedComm (2020)
Peng Y, Zhan L, Shi J, Wang J, Li Y, Sun X, Lv J, Yang H, Qiu Z, Liu X, Li C, Gong S, Jia W, Wang H, Zhao Y, Zhang B, Guo W, Guo J, Shang J, Zhou Q, Yang Y, Gao F.   +21 more
europepmc   +1 more source

MHC Class I/Peptide Stability: Implications for Immunodominance, In Vitro Proliferation, and Diversity of Responding CTL [PDF]

, 1998
Dirk H. Busch, Eric G. Pamer
openalex   +1 more source

Spatial Transcriptomics and snRNA‐seq Expose CAF Niches Orchestrating Dual Stromal‐Immune Barriers in Hepatocellular Carcinoma

Advanced Science, EarlyView.
HmmyCAFs may form a triple immunosuppressive niche: possibly secrete ECM (POSTN, etc.) as physical barriers to block CD8⁺ T cells, induce CD8⁺ T exhaustion via those molecules, and use HIF‐1α‐driven metabolism to create acidic, nutrient‐poor microenvironments that suppress T cells.
Yingxue Li, Changxiang Huan, Haoting Sun, Wei Zhang, Zhen Guo, Chuanyu Li, Jia Yao, Zhiqi Zhang, Shizhe Yu, Qiongzhu Dong, Lunxiu Qin, Jinze Li, Lianqun Zhou   +12 more
wiley   +1 more source

Clinical, radiological, and laboratory assessment of pulmonary eosinophilia syndrome: a case control study in Saudi Arabia. [PDF]

BMC Pulm Med
Ahmed MI, Ali SAM, Ahmed RI.
europepmc   +1 more source

Depletion of IL-10- and TGF-β-Producing Regulatory γδ T Cells by Administering a Daunomycin-Conjugated Specific Monoclonal Antibody in Early Tumor Lesions Augments the Activity of CTLs and NK Cells [PDF]

, 1999
Naohiro Seo, Y. Tokura, Masahiro Takigawa, Kohji Egawa   +3 more
openalex   +1 more source

Enhancing Anti‐Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression

Advanced Science, EarlyView.
CD19‐293‐EV can switch the CD19 endocytosis pathway from clathrin‐mediated endocytosis to aggregation‐dependent endocytosis, leading to lysosomal degradation of the CD19/EVs complex. Degradation of the EVs leads to impairment in the IFN response and enhancement in EV uptake by target cells, creating a potent feedback cycle.
Zixuan Huang, Chaoqun Lu, Yixin Wang, Huajian Xian, Yuling Zheng, Ting Kang, Rufang Xiang, Shufeng Xie, Minghui Wang, Zeyi Li, Xiaoli Xia, Yaoyifu Yu, Wenjie Zhang, Huijian Zheng, Renyao Pan, Dan Li, Chunjun Zhao, Han Liu   +17 more
wiley   +1 more source

CTL Escape Viral Variants

, 1995
Hanna Lewicki, Antoinette Tishon, Persephone Borrow, Claire F. Evans, Jean Edouard Gairin, Klaus M. Hahn, David A. Jewell, Ian A. Wilson, Michael B. A. Oldstone   +8 more
openalex   +1 more source

IL-12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro. [PDF]

, 1996
Nina Bhardwaj, R A Seder, A. Reddy, M V Feldman   +3 more
openalex   +1 more source

Stability of Organic Photovoltaics: From Root Causes to Advanced Analytical Techniques

Advanced Energy Materials, EarlyView.
This review explains the causes and mechanisms of degradation in organic photovoltaics (OPVs). It explores how various factors, including heat, light, oxygen, and inherent material properties, influence OPV stability. The study categorizes degradation pathways and analyzes their impact on device performance, providing insights into the fundamental ...
Yelim Choi, Dohyun Kim, Seung Un Ryu, Hangyeol Kim, Sungryong Kim, Minjun Kim, Taiho Park   +6 more
wiley   +1 more source