Results 21 to 30 of about 436,571 (380)

Pyroptosis-Related Subtypes Predict the Response of Clear Cell Renal Cell Carcinoma to Targeted Therapy

Frontiers in Bioscience-Landmark, 2023
Background: Pyroptosis plays a crucial role in anti-tumor immunity and in formation of the immune microenvironment. However, whether pyroptosis is involved in the progression of clear cell renal cell carcinoma (ccRCC) is still unclear.
Jinpeng Ma, Zhijian Kang, Guang Yang, Xinyue Wang, Minggui Si, Yuting Wang, Guangbin Li, Shiyu Bai, Fanshu Zeng, Min Li, Ziqi Wang, Lu Wang, Wanhai Xu   +12 more
doaj   +1 more source

CTL and Equivalent Sublanguages of CTL [PDF]

, 1997
Specifications of finite state algorithms with a complex temporal behavior such as protocols or hardware systems are often given in temporal logics as e.g. CTL or CTL*. On the one hand, CTL offers in comparison to CTL* efficient model checking algorithms, but on the other hand, CTL seems to suffer from a limited expressiveness.
Klaus Schneider, D. Schmid
openaire   +2 more sources

SON-1210 - a novel bifunctional IL-12 / IL-15 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy

Frontiers in Immunology, 2023
BackgroundThe potential synergy between interleukin-12 (IL-12) and IL-15 holds promise for more effective solid tumor immunotherapy. Nevertheless, previous clinical trials involving therapeutic cytokines have encountered obstacles such as short ...
John K. Cini, Susan Dexter, Darrel J. Rezac, Stephen J. McAndrew, Gael Hedou, Rich Brody, Rukiye-Nazan Eraslan, Richard T. Kenney, Pankaj Mohan   +8 more
doaj   +1 more source

A Peripheral Blood Signature of Increased Th1 and Myeloid Cells Combined with Serum Inflammatory Mediators Is Associated with Response to Abatacept in Rheumatoid Arthritis Patients

Cells, 2023
Abatacept (CTLA4-Ig)—a monoclonal antibody which restricts T cell activation—is an effective treatment for rheumatoid arthritis (RA). Nevertheless, only 50% of RA patients attain clinical responses, while predictors of response are rather limited. Herein,
Panagiota Goutakoli, Garyfalia Papadaki, Argyro Repa, Nestor Avgoustidis, Eleni Kalogiannaki, Irini Flouri, Antonios Bertsias, Jerome Zoidakis, Martina Samiotaki, George Bertsias, Maria Semitekolou, Panayotis Verginis, Prodromos Sidiropoulos   +12 more
doaj   +1 more source

CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function

Frontiers in Immunology, 2017
CD4+ T cells with cytotoxic activity (CD4 CTL) have been observed in various immune responses. These cells are characterized by their ability to secrete granzyme B and perforin and to kill the target cells in an MHC class II-restricted fashion.
A. Takeuchi, T. Saito
semanticscholar   +1 more source

Frequency analysis of cytolytic T lymphocyte precursors (CTL-P) generated in vivo during lethal rabies infection of mice. II. Rabies virus genus specificity of CTL-P [PDF]

, 1984
Cytolytic T lymphocyte precursors (CTL-P) were sensitized in vivo by intraplantar infection of C57BL/6 mice with a lethal dose of rabies virus, strain ERA (ERA).
Aden, Baer, Berke, Cox, Fazekas De, Grimm, Koprowski, Minato, Reddehase, Reddehase, Reddehase, Rosenthal, Rosenthal, Schneider, Sethi, Shope, Shope, Stoker, Taswell, Wiktor, Wiktor, Zinkernagel, Zinkernagel   +22 more
core   +1 more source

Frequency analysis of cytolytic T cell precursors (CTL-P) generated in vivo during lethal rabies infection of mice. I. Distinction of CTL-P with different interleukin 2 sensitivity [PDF]

, 1982
The aim of this study was to determine the number and state of activity of cytolytic T lymphocytes (CTL) and their precursors (CTL-P) present in vivo during the early stages of viral infection. The local response to lethal infection with rabies virus was
Cerottini, Fischer Lindahl, Gillis, Hardt, Komatsu, Koszinowski, Lagrange, Lefkovits, Miller, Plate, Ryser, Schneider, Skinner, Smith, Smith, Teh, Wagner, Wagner, Wiktor, Wiktor, Wiktor, Zinkernagel   +21 more
core   +1 more source

Model with two types of CTL regulation and experiments on CTL dynamics [PDF]

Journal of Theoretical Biology, 2010
Recently, we developed a mathematical model of interaction between the HIV and the immune system to match various dynamic experiments carried out in HIV-infected humans and SIV-infected macaques. The model includes helper cell-dependent and helper cell-independent cytotoxic lymphocytes (CTLs) and predicts two stable steady states, a state with a high ...
R.A. Sergeev, Rebecca Batorsky, Igor M. Rouzine   +2 more
openaire   +3 more sources

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Nature, 2015
Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a stable latent reservoir, primarily in resting memory CD4+ T cells. This reservoir presents a major barrier to the cure of HIV-1 infection.
K. Deng, M. Perțea, A. Rongvaux, Leyao Wang, C. Durand, G. Ghiaur, J. Lai, H. McHugh, Haiping Hao, Hao Zhang, J. Margolick, C. Gurer, A. Murphy, D. Valenzuela, G. Yancopoulos, S. Deeks, T. Strowig, Priti Kumar, J. Siliciano, S. Salzberg, R. Flavell, L. Shan, R. Siliciano   +22 more
semanticscholar   +1 more source

Motor, memory, and anxiety-like behavioral impairments associated with brain-derived neurotrophic factor and dopaminergic imbalance after inhalational exposure to deltamethrin

Brain Research Bulletin, 2022
Believed to cause damage to the nervous system and possibly being associated with neurodegenerative diseases, deltamethrin (DM) is a type II pyrethroid used in pest control, public health, home environment, and vector control. The objective of this study
Marina F. Souza, Katty A.A.L. Medeiros, Lívia C.R.F. Lins, José M.M. Bispo, Auderlan M. Gois, Edson R. Santos, Thiago H. Almeida-Souza, João E.C. Melo, Heitor S. Franco, Rodolfo S. Silva, Eduardo A. Pereira-Filho, Marco Aurelio M. Freire, José R. Santos   +12 more
doaj   +1 more source