Results 311 to 320 of about 436,571 (380)

B cells induced regulatory T cells attenuated the classical M1 polarization of mouse bone marrow-derived macrophages. [PDF]

Sci Rep
Huang YP, Chien CH, Wang LC, Chiang BL.
europepmc   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

Prognostic relevance of TROP2 expression in patients with non-small cell lung cancer receiving immunotherapy. [PDF]

Sci Rep
Hashimoto N, Takei S, Kaira K, Imai H, Hashimoto K, Miura Y, Shiono A, Yamaguchi O, Mouri A, Kobayashi K, Hamda M, Kagamu H.   +11 more
europepmc   +1 more source

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis

Cancer Communications, EarlyView.
Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM.
Yizhi Zhan, Jinsong Xu, Zhanqiao Zhang, Yating Hu, Yongsheng Li, Junying Qian, Yunyan Ling, Dehua Wu, Haijun Deng, Guoxin Li, Zhiyong Shen, Yuan Fang   +11 more
wiley   +1 more source

HTLV-1 p12 is cleaved to p8 by the signal peptidase complex and its inhibition impairs p8-dependent transmission. [PDF]

PLoS Pathog
Simon F, Donhauser N, Kemeter LM, Wittdorf F, Millen S, Sticht H, Thoma-Kress AK.   +6 more
europepmc   +1 more source

B cell-associated research in non-small cell lung cancer: a bibliometric analysis of current landscapes and future directions. [PDF]

Discov Oncol
Zhang Y, Chen X, Mai W, Wang L, Wang Y, Ma C, Li H.   +6 more
europepmc   +1 more source

Stereotactic body radiotherapy plus cadonilimab (PD‐1/CTLA‐4 bispecific antibody) as third‐line or beyond therapy for refractory solid tumors: A phase 1b study

Cancer Communications, EarlyView.
Abstract Background Cadonilimab is a humanized immunoglobulin G1 bispecific antibody targeting programmed cell death protein 1 (PD‐1) and cytotoxic T‐lymphocyte‐associated antigen 4 (CTLA‐4). This study aimed to evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) combined with cadonilimab in patients with advanced recurrent or ...
Yao Xiao, Yuxia Wang, Jun Li, Cheng Cheng, Chunyong Song, Xin Wang, Liyuan Tao, Hongqing Zhuang   +7 more
wiley   +1 more source

m6A‐modified EHD1 controls PD‐L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma

Cancer Communications, EarlyView.
Abstract Background Eps15 homology domain (EHD) proteins, including EHD1 to EHD4, play vital roles in tumor progression. In this study, we aimed to investigate which specific EHD proteins, if any, are implicated in tumor immune evasion and immunotherapy response.
Fanglin Tian, Jian Huang, Weina Fan, Xin Li, Yuning Zhan, Kexin Zhu, Xiangyu Wang, Xin Hong, Xin Wang, Jin Ren, Ying Xing, Li Cai   +11 more
wiley   +1 more source

Aging microenvironment in osteoarthritis focusing on early-stage alterations and targeted therapies. [PDF]

Bone Res
Dang Y, Liu Y, Zhang B, Zhang X.
europepmc   +1 more source