Results 321 to 330 of about 436,571 (380)

Cancer-immune coevolution dictated by antigenic mutation accumulation. [PDF]

Elife
Wang L, Morison C, Huang W.
europepmc   +1 more source

(MU-CTL-01-14) SimSYS Game Specification [PDF]

, 2014
Cooper, Kendra, Jayaraj, Hemalochane, Longstreet, C. Shaun, Raiker, Riddhi   +3 more
core   +1 more source

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, EarlyView.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source

Lipin3 deficiency promotes hepatocyte ferroptosis and pyroptosis via activating JAK1-STAT3 pathway during acetaminophen induced acute liver injury. [PDF]

Mol Biomed
Liu YX, Wang Q, Xiangyang ZY, Long JY, Huang H, Fan LL.   +5 more
europepmc   +1 more source

CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer

Cancer Communications, EarlyView.
Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang, Guoshu Bi, Xiaolong Huang, Zhijie Xu, Yiwei Huang, Yunyi Bian, Guangyao Shan, Wei Guo, Yuanliang Yan, Qihai Sui, Xiaodong Yang, Zhencong Chen, Tao Lu, Huan Zhang, Qun Wang, Wei Jiang, Cheng Zhan   +16 more
wiley   +1 more source

The multifaceted impact of stress on immune function. [PDF]

Mol Biol Rep
Balcerowska M, Kwaśnik P.
europepmc   +1 more source

Efficacy of Essential Oil of Algrizea minor Sobral, Faria & Proença (Myrtaceae) in Combating Methicillin‐resistant Staphylococcus aureus: Antibacterial and Virulence Modulation Studies Conducted In Vitro and In Vivo

Chemistry &Biodiversity, EarlyView.
This study explored the antibacterial, antivirulence, and in vivo effects of Algrizea minor essential oil (EOAM), against MRSA isolates. Chemical analysis by GC‐MS has been performed. The oil exhibited synergistic effects when combined with amoxicillin and oxacillin, inhibiting biofilm formation and reducing S. aureus‐induced hemolysis.
Amanda Vieira de Barros, Bruno Oliveira de Veras, Henrique Nelson Pereira Costa Júnior, Raudiney Frankilin Vasconcelos Mendes, Patryck Érmerson Monteiro dos Santos, Jael Fernandes Tavares, Daniela Maria do Amaral Ferraz Navarro, Rafael Matos Ximenes, Patrícia Maria Guedes Paiva, Clovis Macedo Bezerra Filho, Josinaldo Alves da Silva, Márcia Vanusa da Silva, João Paulo Martins de Lima, Henrique Douglas Melo Coutinho, Maria Betânia Melo de Oliveira   +14 more
wiley   +1 more source

Tumor-associated macrophages in meningiomas: a novel biomarker for poor survival outperforming the benefits of T cells. [PDF]

Acta Neuropathol
Lotsch C, Warta R, Liu F, Jungwirth G, Rommel C, Barthel M, Lamszus K, Kessler AF, Grabe N, Loehr M, Ketter R, Senft C, Maas SLN, Sievers P, Westphal M, Krieg SM, Unterberg A, Simon M, von Deimling A, Sahm F, Raleigh DR, Herold-Mende C.   +21 more
europepmc   +1 more source

Design and Characterization of Prodrugged Anti‐CTLA‐4 Antibodies

ChemBioChem, Accepted Article.
Therapeutic antibodies are widely used to treat diseases like cancer and inflammatory conditions by binding with high specificity to their molecular targets. Masking is a strategy to mitigate undesirable activity in non‐target tissues, improving safety and pharmacokinetic (PK) profiles by reducing target‐mediated drug disposition (TMDD). In this study,
Sayumi Yamazoe, Mary Huber, Srikanth Kotapati, Rahima Akter, Aarti Jashnani, Suprit Deol, Christine Bee, John Engelhart, Yam B Poudel, Stanley Krystek, Mohan Srinivasan, Arvind Rajpal, Yong Zhang, Pavel Strop, Chetana Rao, John Haugner   +15 more
wiley   +1 more source

Micro-nano microbial fuel cell-driven bioelectrochemical tumor therapy. [PDF]

Nat Commun
Li R, Kang Y, Ran N, Niu G, Fan Y, Zhang Y, Ye J, Yuan X, Shi J, Ding M, Zhang Y, Ji X.   +11 more
europepmc   +1 more source