Results 41 to 50 of about 399,115 (333)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Discovering novel genomic regions explaining adaptation of bread wheat to conservation agriculture through GWAS

Scientific Reports
To sustainably increase wheat yield to meet the growing world population’s food demand in the face of climate change, Conservation Agriculture (CA) is a promising approach. Still, there is a lack of genomic studies investigating the genetic basis of crop
Amit Kumar Mazumder, Rajbir Yadav, Manjeet Kumar, Prashanth Babu, Naresh Kumar, Sanjay Kumar Singh, Amolkumar U. Solanke, Shabir H. Wani, Adel I. Alalawy, Abdulrahman Alasmari, Kiran B. Gaikwad   +10 more
doaj   +1 more source

Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes [PDF]

, 1980
Two populations of cytolytic T lymphocytes (CTL) generated after influenza A virus infection can be distinguished into one with specificity for the sensitizing hemagglutinin type and a second with cross-reactivity for antigens induced by other type-A ...
Allen, H., Gething, M. J., Klenk, H. D., Koszinowski, Ulrich H., Waterfield, M. D.   +4 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

THE COMPLEXITY OF SATISFIABILITY FOR FRAGMENTS OF CTL AND CTL⋆ [PDF]

International Journal of Foundations of Computer Science, 2008
The satisfiability problems for [Formula: see text] and [Formula: see text] are known to be EXPTIME-complete, resp. 2EXPTIME-complete (Fischer and Ladner (1979), Vardi and Stockmeyer (1985)). For fragments that use less temporal or propositional operators, the complexity may decrease.
Meier, Arne, Mundhenk, Martin, Thomas, Michael, Vollmer, Heribert   +3 more
openaire   +1 more source

Alloreactive cytotoxic T lymphocytes generated in the presence of viral- derived peptides show exquisite peptide and MHC specificity [PDF]

, 1993
The nature of alloreactivity to MHC molecules has been enigmatic, primarily because of the observation that allogeneic responses are considerably stronger than syngeneic responses. To better determine the specificity potential of allogeneic responses, we
Alexander-Miller, M. A., Burke, K., Connolly, J. M., Hansen, T. H., Koszinowski, Ulrich H.   +4 more
core  

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

The effects of trans fat diet intake on metabolic parameters and pancreatic tissue in offspring of prenatal bisphenol A exposed rats

Scientific Reports, 2023
Bisphenol A (BPA) is a plasticiser used in the manufacturing of many products and its effects on human health remain controversial. Up till now, BPA involvement in metabolic syndrome risk and development is still not fully understood.
Hala Abulehia, Noor Shafina Mohd Nor, Siti Hamimah Sheikh Abdul Kadir, Mardiana Abdul Aziz, Sarah Zulkifli   +4 more
doaj   +1 more source

The Role of Immunotherapy in the Treatment of Adrenocortical Carcinoma

Biomedicines, 2021
Adrenocortical carcinoma (ACC) is a rare epithelial neoplasm, with a high tendency for local invasion and distant metastases, with limited treatment options. Surgical treatment is the method of choice.
Izabela Karwacka, Łukasz Obołończyk, Sonia Kaniuka-Jakubowska, Krzysztof Sworczak   +3 more
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source