Results 51 to 60 of about 392,395 (399)

A stratified phase I dose escalation trial of hypofractionated radiotherapy followed by ipilimumab in metastatic melanoma: long-term follow-up and final outcomes

OncoImmunology, 2021
We conducted a phase I dose-escalation trial of radiation with ipilimumab in patients with melanoma with ≥2 metastatic lesions. Here, we report the final full clinical analysis.
Amit Maity, Rosemarie Mick, Ramesh Rengan, Tara C. Mitchell, Ravi K. Amaravadi, Lynn M. Schuchter, Daniel A. Pryma, Dana M. Patsch, Alisha P. Maity, Andy J. Minn, Robert H. Vonderheide, John N. Lukens   +11 more
doaj   +1 more source

Analysis of an HTLV/HIV dual infection model with diffusion

Mathematical Biosciences and Engineering, 2021
In the literature, several HTLV-I and HIV single infections models with spatial dependence have been developed and analyzed. However, modeling HTLV/HIV dual infection with diffusion has not been studied. In this work we derive and investigate a PDE model
A. M. Elaiw, N. H. AlShamrani
doaj   +1 more source

Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients

OncoImmunology, 2021
The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti ...
Kaat de Jonge, Laure Tillé, Joao Lourenco, Hélène Maby-El Hajjami, Sina Nassiri, Julien Racle, David Gfeller, Mauro Delorenzi, Grégory Verdeil, Petra Baumgaertner, Daniel E. Speiser   +10 more
doaj   +1 more source

Model Checking CTL is Almost Always Inherently Sequential [PDF]

, 2009
The model checking problem for CTL is known to be P-complete (Clarke, Emerson, and Sistla (1986), see Schnoebelen (2002)). We consider fragments of CTL obtained by restricting the use of temporal modalities or the use of negations—restrictions already ...
Beyersdorff, Olaf, Meier, Arne, Mundhenk, Martin, Schneiden, Thomas, Schneider, Thomas, Thomas, Michael, Vollmer, Heribert   +6 more
core   +4 more sources

TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients

OncoImmunology, 2021
Accumulating evidence indicates that immune checkpoint inhibitors (ICIs) can restore CD8+ cytotoxic T lymphocyte (CTL) functions in preclinical models of acute myeloid leukemia (AML).
Jana Rakova, Iva Truxova, Peter Holicek, Cyril Salek, Michal Hensler, Lenka Kasikova, Josef Pasulka, Monika Holubova, Marek Kovar, Daniel Lysak, Justin P. Kline, Zdenek Racil, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova   +14 more
doaj   +1 more source

Elevated Levels of Soluble CTLA-4, PD-1, PD-L1, LAG-3 and TIM-3 and Systemic Inflammatory Stress as Potential Contributors to Immune Suppression and Generalized Tumorigenesis in a Cohort of South African Xeroderma Pigmentosum Patients

Frontiers in Oncology, 2022
Xeroderma Pigmentosum (XP), an autosomal recessive disorder characterized by ultraviolet radiation-induced abnormalities of DNA excision and repair pathways is associated with early development of cutaneous cancers.
Mahlatse C. M. Kgokolo, Katherine Anderson, Shalate C. Siwele, Helen C. Steel, Luyanda L. I. Kwofie, Luyanda L. I. Kwofie, Mike M. Sathekge, Pieter W. A. Meyer, Pieter W. A. Meyer, Bernardo L. Rapoport, Bernardo L. Rapoport, Ronald Anderson   +11 more
doaj   +1 more source

Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice.

Journal of Clinical Investigation, 2010
Cancer immunotherapy faces a serious challenge because of low clinical efficacy. Recently, a number of clinical studies have reported the serendipitous finding of high rates of objective clinical response when cancer vaccines are combined with ...
R. Ramakrishnan, D. Assudani, S. Nagaraj, T. Hunter, Hyun-Il Cho, S. Antonia, S. Altiok, E. Celis, D. Gabrilovich   +8 more
semanticscholar   +1 more source

CTL-Derived Exosomes Enhance the Activation of CTLs Stimulated by Low-Affinity Peptides [PDF]

Frontiers in Immunology, 2019
Abstract Cytotoxic T cells (CTLs) of low TCR affinity play an important role in the control of intracellular pathogens and cancers; however, the mechanisms by which lower-affinity CTLs are activated and maintained are not well understood.
Zhengguo Xiao, Yan Wang, Lei Li, Shu-Wei Wu   +3 more
openaire   +4 more sources

CTLs: Killers of intracellular bacteria

Frontiers in Cellular and Infection Microbiology, 2022
Many microbial pathogens have evolved a range of capabilities to evade host immune defense mechanisms and to survive and multiply in host cells. The presence of host intracellular bacteria makes it difficult for specific antibodies to function. After the intracellular bacteria escape the attack of the innate immune system, such as phagocytes, they ...
Li Tian, Wei Zhou, Xianwei Wu, Zhuannan Hu, Lei Qiu, Huiyong Zhang, Xue Chen, Shaoyan Zhang, Zhenhui Lu   +8 more
openaire   +3 more sources

License to kill: microsatellite instability and immune contexture

OncoImmunology, 2021
Colorectal cancers (CRCs) with microsatellite instability (MSI) are due to a defect in the DNA mismatch repair (MMR) system resulting in an accumulation of frame-shift mutations.
Pauline Maby, Gabriela Bindea, Bernhard Mlecnik, Jérôme Galon   +3 more
doaj   +1 more source