Results 61 to 70 of about 436,571 (380)

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Discovering novel genomic regions explaining adaptation of bread wheat to conservation agriculture through GWAS

Scientific Reports
To sustainably increase wheat yield to meet the growing world population’s food demand in the face of climate change, Conservation Agriculture (CA) is a promising approach. Still, there is a lack of genomic studies investigating the genetic basis of crop
Amit Kumar Mazumder, Rajbir Yadav, Manjeet Kumar, Prashanth Babu, Naresh Kumar, Sanjay Kumar Singh, Amolkumar U. Solanke, Shabir H. Wani, Adel I. Alalawy, Abdulrahman Alasmari, Kiran B. Gaikwad   +10 more
doaj   +1 more source

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues.

Journal of Immunology, 1996
Recognition of the melanoma Ag gp100 by tumor-infiltrating lymphocytes (TIL) in vitro has been correlated with tumor regression in patients with metastatic melanoma treated with the adoptive transfer of TIL plus IL-2.
M. Parkhurst, M. Salgaller, S. Southwood, P. Robbins, A. Sette, S. Rosenberg, Y. Kawakami   +6 more
semanticscholar   +1 more source

CTL Model Update for System Modifications [PDF]

Journal of Artificial Intelligence Research, 2011
Model checking is a promising technology, which has been applied for verification of many hardware and software systems. In this paper, we introduce the concept of model update towards the development of an automatic system modification tool that extends
Yulin Ding, Y. Zhang
semanticscholar   +1 more source

Efficient CTL Verification via Horn Constraints Solving [PDF]

, 2016
The use of temporal logics has long been recognised as a fundamental approach to the formal specification and verification of reactive systems. In this paper, we take on the problem of automatically verifying a temporal property, given by a CTL formula ...
Beyene, Tewodros A., Popeea, Corneliu, Rybalchenko, Andrey   +2 more
core   +2 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

On CTL* with Graded Path Modalities [PDF]

Information and Computation, 2015
Graded path modalities count the number of paths satisfying a property, and generalize the existential $$\mathsf {E}$$ and universal $$\mathsf {A}$$ path modalities of $$\textsc {CTL}^{*}$$. The resulting logic is denoted $$\textsc {G}\textsc {CTL}^{*}$$, and is a very powerful logic since as we show it is equivalent, over trees, to monadic path logic.
Aminof, Benjamin, Murano, Aniello, Rubin, Sasha   +2 more
openaire   +6 more sources

Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/MART-1 immunodominant peptide analogues.

Journal of Immunology, 1998
The Melan-A/MART-1 gene, which is expressed by normal melanocytes as well as by most fresh melanoma samples and melanoma cell lines, codes for Ags recognized by tumor-reactive CTL.
D. Valmori, J. Fonteneau, Concepción Marañón Lizana, N. Gervois, D. Liénard, D. Liénard, D. Rimoldi, V. Jongeneel, F. Jotereau, J. Cerottini, J. Cerottini, Pedro Romero, Pedro Romero   +12 more
semanticscholar   +1 more source

Alloreactive cytotoxic T lymphocytes generated in the presence of viral- derived peptides show exquisite peptide and MHC specificity [PDF]

, 1993
The nature of alloreactivity to MHC molecules has been enigmatic, primarily because of the observation that allogeneic responses are considerably stronger than syngeneic responses. To better determine the specificity potential of allogeneic responses, we
Alexander-Miller, M. A., Burke, K., Connolly, J. M., Hansen, T. H., Koszinowski, Ulrich H.   +4 more
core  

Role of early viral surface antigens in cellular immune response to vaccinia virus [PDF]

, 1976
Infection of mice with the vaccinia virus strain WR, Elstree or DIs, a conditional lethal mutant of vaccinia virus, resulted in the generation of vaccinia virus-specific sensitized cytolytic T lymphocytes (CTL).
Ertl, H., Koszinowski, Ulrich H.
core   +1 more source