Results 71 to 80 of about 399,115 (333)
Advanced Functional Materials, EarlyView.A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo +7 more
wiley +1 more source
From Quantified CTL to QBF [PDF]
, 2019 QCTL extends the temporal logic CTL with quantifications over atomic propositions. This extension is known to be very expressive: QCTL allows us to express complex properties over Kripke structures (it is as expressive as MSO).
Hossain, Akash
core +1 more source
Advanced Functional Materials, EarlyView.Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava +7 more
wiley +1 more source
Model with two types of CTL regulation and experiments on CTL dynamics [PDF]
Journal of Theoretical Biology, 2010 Recently, we developed a mathematical model of interaction between the HIV and the immune system to match various dynamic experiments carried out in HIV-infected humans and SIV-infected macaques. The model includes helper cell-dependent and helper cell-independent cytotoxic lymphocytes (CTLs) and predicts two stable steady states, a state with a high ...
Sergeev, R. A. +2 more
openaire +3 more sources
Enriched MU-Calculi Module Checking [PDF]
, 2008 The model checking problem for open systems has been intensively studied in the literature, for both finite-state (module checking) and infinite-state (pushdown module checking) systems, with respect to Ctl and Ctl*. In this paper, we further investigate
Aniello Murano +3 more
core +2 more sources
Synthetic Cell‐Based Tissues for Bottom‐Up Assembly of Artificial Lymphatic Organs
Advanced Healthcare Materials, EarlyView.Synthetic cells have emerged as a novel biomimetic approach for fundamental research and therapeutic interventions. T cell activating synthetic cells are able to form 3D tissue‐like structures by self‐assembly into lymphatic bottom‐up tissues (lymphBUT) with tunable biochemical and biomechanical functionalities as well as metabolic activity are ...
Anna Burgstaller +5 more
wiley +1 more source
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
Immunity & Ageing, 2023 Background Although the concept of declined immune function associated with cancer has been accepted extensively, real-world clinical studies focusing on analysis of the peripheral blood immune changes underlying ageing, immunity and cancer are scarce ...
Xiaomin Fu +13 more
doaj +1 more source
On the Complexity of ATL and ATL* Module Checking
, 2017 Module checking has been introduced in late 1990s to verify open systems, i.e., systems whose behavior depends on the continuous interaction with the environment.
Bozzelli, Laura, Murano, Aniello
core +1 more source
IL‐2 Free Expansion of T Cells with Immunofilaments
Advanced Healthcare Materials, EarlyView.Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck +4 more
wiley +1 more source
Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. [PDF]
, 2003 CD8+ class I-restricted cytotoxic T lymphocytes (CTLs) usually incompletely suppress HIV-1 in vivo, and while analogous partial suppression induces antiretroviral drug-resistance mutations, epitope escape mutations are inconsistently observed.
Ali, Ayub +6 more
core